Evidence map›Paper›PMID 19286844›Full record

ArticleThe Journal of rheumatology2009

Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.

Marie Feser, Lezlie A Derber, Kevin D Deane, Dennis C Lezotte, Michael H Weisman, Jane H Buckner, Ted Mikuls, James O'Dell, Peter K Gregersen, V Michael Holers and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Genetic and environmental risk factors for rheumatoid arthritis.Best practice & research. Clinical rheumatology · 2017
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Marie FeserDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA.
Lezlie A Derber
Kevin D Deane
Dennis C Lezotte
Michael H Weisman
Jane H Buckner
Ted Mikuls
James O'Dell
Peter K Gregersen
V Michael Holers
Jill M Norris
Colorado School of Public Health · USUniversity of Colorado Denver · USCedars-Sinai Medical Center · USCenter for Rheumatology · USNebraska Medical Center · USNorthwell Health · USVirginia Mason Medical Center · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI WANG, CHRISTINA C. · 1985 to 2011
$74.2M
Virginia Mason/UCHSC Autoimmune Prevention CenterU19AI050864 · NIAID · UNIVERSITY OF COLORADO DENVER · PI NEPOM, GERALD T · 2001 to 2011
$29.2M
ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$22.1M
RA-Related Autoantibodies in Healthy FDR of RA PatientsR01AR051394 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI NORRIS, JILL M · 2005 to 2011
$3.0M
Genetics, Exposures, and RA-Related AutoimmunityK23AR051461 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI DEANE, KEVIN · 2004 to 2008
$657k
NCRR NIH HHS M01 RR000069NCRR NIH HHS M01 RR000425NIAID NIH HHS U19 AI050864NIAMS NIH HHS K23 AR051461NIAMS NIH HHS R01 AR051394
6 · The paper itself

Abstract

objectiveTo evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA.

methodsIn 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort.

results25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63).

conclusionVitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.

Indexed as

AdultArthritis, RheumatoidBiomarkersFemaleHumansImmunoglobulinsMaleMiddle AgedPeptides, CyclicRheumatoid FactorRisk FactorsVitamin D25-hydroxyvitamin DBiomarkerscyclic citrullinated peptideImmunoglobulinsPeptides, CyclicRheumatoid FactorVitamin D

Identifiers

PMID19286844
PMCPMC2745328
OpenAlexW2113599630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.