ArticleThe Journal of biological chemistry2009
Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Role of the Plasminogen Activation System in Liver Injury and Repair: Knowns and Known Unknowns.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The Role of Extracellular Proteases and Extracellular Matrix Remodeling in the Pre-Metastatic Niche.Biomolecules · 2025Review
- Review
- iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine.International journal of molecular sciences · 2020Review
- The Role of Complement in Liver Injury, Regeneration, and Transplantation.Hepatology (Baltimore, Md.) · 2019Review
- HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis.British journal of cancer · 2019Article
- Mechanisms and biomarkers of liver regeneration after drug-induced liver injury.Advances in pharmacology (San Diego, Calif.) · 2019Review
- Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.Development (Cambridge, England) · 2017Article
- Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors.International journal of peptide research and therapeutics · 2017Article
- Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism.Molecular cancer research : MCR · 2012Article
- A novel animal model for in vivo study of liver cancer metastasis.World journal of gastroenterology · 2012Article
- Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro.Biophysical journal · 2011Article
- Plasmin is essential in preventing periodontitis in mice.The American journal of pathology · 2011Article
- c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase.Oncogene · 2011Article
- The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice.The Journal of clinical investigation · 2010Article
- Does plasmin have anticoagulant activity?Vascular health and risk management · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The physiological relevance of the activation of hepatocyte growth factor (Hgf) by the plasminogen (Plg) system of proteases and its contribution to tissue repair are largely undefined. Here, we investigated whether the defective liver repair in mice lacking Plg is due to impaired activation of Hgf. Loss of Plg in vivo suppressed Hgf activation and signaling through its Met tyrosine kinase receptor. Without Plg, hepatocytes were unresponsive to Hgf-induced proliferation and migration, with a more pronounced impairment in hepatocyte movement within the hepatic environment. Most notably, circumventing the defect in proteolytic activation of Hgf by the downstream expression of an activated Met receptor corrected the functional deficits and improved liver repair in Plg-deficient mice. These findings support a fibrinolysis-unrelated role for Plg in modulating cell proliferation and migration by activation of Hgf.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.