Evidence map›Paper›PMID 19286579›Full record

Trial reportStroke2009

Effects of combined peripheral nerve stimulation and brain polarization on performance of a motor sequence task after chronic stroke.

Pablo Celnik, Nam-Jong Paik, Yves Vandermeeren, Michael Dimyan, Leonardo G Cohen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01207336 (Effect of Combined Anodal tDCS and Peripheral Nerve Stimulation on Motor Recovery in Acute Stroke), which is not on this map. Cited by 86 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01207336 nacompletednot on this mapstarted 2010, after this paper: background citation

Effect of Combined Anodal tDCS and Peripheral Nerve Stimulation on Motor Recovery in Acute Stroke

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2010 to 2012Enrolled20ConditionsAcute Ischaemic StrokeArmscombined transcranial direct current stimulation and electrical peripheral nerve stimulation, Combined transcranial placebo cortical stimulation (placebo tDCS)
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Effects of non-invasive brain stimulation on post-stroke dysphagia: A systematic review and meta-analysis of randomized controlled trials.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016
    Pooled it
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  9. Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment.Neuromodulation : journal of the International Neuromodulation Society · 2018
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  17. Characterizing the application of transcranial direct current stimulation in human pharyngeal motor cortex.American journal of physiology. Gastrointestinal and liver physiology · 2009
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  19. Review
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pablo CelnikHuman Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. pcelnik@jhmi.edu
Nam-Jong Paik
Yves Vandermeeren
Michael Dimyan
Leonardo G Cohen

Funding

Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Rehabilitation Medicine Scientist Training (RMST) ProgramK12HD001097 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 1995 to 2016
$14.1M
Novel Strategies to Enhance Motor Function After StrokeR01HD053793 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CELNIK, PABLO ARIEL · 2007 to 2019
$5.2M
NICHD NIH HHS 5K12HD001097NICHD NIH HHS K12 HD001097NICHD NIH HHS R01 HD053793NICHD NIH HHS R01HD053793
6 · The paper itself

Abstract

background and purposeRecent work demonstrated that application of peripheral nerve and cortical stimulation independently can induce modest improvements in motor performance in patients with stroke. The purpose of this study was to test the hypothesis that combining peripheral nerve stimulation (PNS) to the paretic hand with anodal direct current stimulation (tDCS) to the ipsilesional primary motor cortex (M1) would facilitate beneficial effects of motor training more than each intervention alone or sham (tDCS(Sham) and PNS(Sham)).

methodsNine chronic stroke patients completed a blinded crossover designed study. In separate sessions, we investigated the effects of single applications of PNS+tDCS, PNS+tDCS(Sham), tDCS+PNS(Sham), and PNS(Sham)+tDCS(Sham) before motor training on the ability to perform finger motor sequences with the paretic hand.

resultsPNS+tDCS resulted in a 41.3% improvement in the number of correct key presses relative to PNS(Sham)+tDCS(Sham), 15.4% relative to PNS+tDCS(Sham), and 22.7% relative to tDCS+PNS(Sham). These performance differences were maintained 1 and 6 days after the end of the training.

conclusionsThese results indicate that combining PNS with tDCS can facilitate the beneficial effects of training on motor performance beyond levels reached with each intervention alone, a finding of relevance for the neurorehabilitation of motor impairments after stroke.

Indexed as

Electric Stimulation TherapyAdultAgedAnalysis of VarianceAttentionBrainCombined Modality TherapyCross-Over StudiesData Interpretation, StatisticalFemaleFunctional LateralityHumansMaleMedian NerveMiddle AgedMotor Cortex

Identifiers

PMID19286579
PMCPMC2692264

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.