ReviewJournal of molecular and cellular cardiology2009
Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling.
Review in Journal of molecular and cellular cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 118 citations in OpenAlex.
- Epigenetic reprogramming of mtDNA and its etiology in mitochondrial diseases.Journal of physiology and biochemistry · 2024Review
- Mitochondria as the Essence of Yang Qi in the Human Body.Phenomics (Cham, Switzerland) · 2022Review
- The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction.The Journal of physiology · 2021Review
- Article
- Mitochondrial CaCells · 2021Review
- Narrative review of metabolomics in cardiovascular disease.Journal of thoracic disease · 2021Review
- Key Role of MCUR1 in Malignant Progression of Breast Cancer.OncoTargets and therapy · 2021Article
- T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.Cell calcium · 2021Article
- Review
- Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease.Cell calcium · 2018Article
- The machineries, regulation and cellular functions of mitochondrial calcium.Nature reviews. Molecular cell biology · 2018Review
- Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition.Cell death and differentiation · 2018Article
- Effects of luteolin on regulatory proteins and enzymes for myocyte calcium circulation in hypothermic preserved rat heart.Experimental and therapeutic medicine · 2018Article
- FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress.American journal of physiology. Heart and circulatory physiology · 2016Article
- Combined effect of G3139 and TSPO ligands on Ca(2+)-induced permeability transition in rat brain mitochondria.Archives of biochemistry and biophysics · 2015Article
- Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.The Journal of biological chemistry · 2015Article
- Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.Cardiovascular research · 2015Article
- Lipid metabolism, apoptosis and cancer therapy.International journal of molecular sciences · 2015Review
- The destiny of Ca(2+) released by mitochondria.The journal of physiological sciences : JPS · 2015Review
- A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5.The Journal of biological chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transient increases in intracellular calcium concentration activate and coordinate a wide variety of cellular processes in virtually every cell type. This review describes the main homeostatic mechanisms that control Ca(2+) transients, focusing on the mitochondrial checkpoint. We subsequently extend this paradigm to the cardiomyocyte and to the interplay between cytosol, endoplasmic reticulum and mitochondria that occurs beat-to-beat in excitation-contraction coupling. The mechanisms whereby mitochondria decode fast cytosolic calcium spikes are discussed in the light of the results obtained with recombinant photoproteins targeted to the mitochondrial matrix of contracting cardiomyocytes. Mitochondrial calcium homeostasis is then highlighted as a crucial point of convergence of the environmental signals that mediate cardiac cell death, both by necrosis and by apoptosis. Altogether we point to a role of the mitochondrion as an integrator of calcium signalling and a fundamental decision maker in cardiomyocyte metabolism and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.