ArticleMolecular cell2009
Resampling and editing of mischarged tRNA prior to translation elongation.
Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity.Nucleic acids research · 2025Article
- Strategies for detecting aminoacylation and aminoacyl-tRNA editingIsrael journal of chemistry · 2024Article
- Article
- The role of tRNA identity elements in aminoacyl-tRNA editing.Frontiers in microbiology · 2024Review
- Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases.Nucleic acids research · 2022Article
- Increase in Ribosomal Fidelity BenefitsGenes · 2022Article
- Study on the Metabonomics Mechanism of Mongolian Medical Andai Therapy on Healthy People.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Impact of alanyl-tRNA synthetase editing deficiency in yeast.Nucleic acids research · 2021Article
- HumanThe Journal of biological chemistry · 2020Article
- Chiral checkpoints during protein biosynthesis.The Journal of biological chemistry · 2019Review
- Principles of tRNAACS omega · 2019Article
- Comparative Proteomic Analysis of Wheat CarryingInternational journal of molecular sciences · 2019Article
- Stoichiometry of triple-sieve tRNA editing complex ensures fidelity of aminoacyl-tRNA formation.Nucleic acids research · 2019Article
- Distinct ways of G:U recognition by conserved tRNA binding motifs.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Translational fidelity and mistranslation in the cellular response to stress.Nature microbiology · 2017Review
- Article
- Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation.ACS central science · 2017Article
- Aminoacyl-tRNA Synthetases in the Bacterial World.EcoSal Plus · 2016Review
- Naturally Occurring Isoleucyl-tRNA Synthetase without tRNA-dependent Pre-transfer Editing.The Journal of biological chemistry · 2016Article
- Trans-oligomerization of duplicated aminoacyl-tRNA synthetases maintains genetic code fidelity under stress.Nucleic acids research · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Faithful translation of the genetic code depends on the GTPase EF-Tu delivering correctly charged aminoacyl-tRNAs to the ribosome for pairing with cognate codons. The accurate coupling of cognate amino acids and tRNAs by the aminoacyl-tRNA synthetases is achieved through a combination of substrate specificity and product editing. Once released by aminoacyl-tRNA synthetases, both cognate and near-cognate aminoacyl-tRNAs were considered to be committed to ribosomal protein synthesis through their association with EF-Tu. Here we show instead that aminoacyl-tRNAs in ternary complex with EF-Tu*GTP can readily dissociate and rebind to aminoacyl-tRNA synthetases. For mischarged species, this allows resampling by the product editing pathway, leading to a reduction in the overall error rate of aminoacyl-tRNA synthesis. Resampling of mischarged tRNAs was shown to increase the accuracy of translation over ten fold during in vitro protein synthesis, supporting the presence of an additional quality control step prior to translation elongation.
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