ReviewCurrent opinion in cell biology2009
Translational control from head to tail.
Review in Current opinion in cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Translational control of cell growth and malignancy by the CPEBs.Nature reviews. Cancer · 2013Pooled it
- Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression.Nature reviews. Molecular cell biology · 2022Review
- Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation.The Journal of comparative neurology · 2021Article
- Phosphorylation of the mRNA cap-binding protein eIF4E and cancer.Cellular signalling · 2020Review
- Article
- Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala.eLife · 2019Article
- Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity.Epigenetics · 2019Article
- Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Shifting patterns of polyribosome accumulation at synapses over the course of hippocampal long-term potentiation.Hippocampus · 2018Article
- Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Integrated Translatome and Proteome: Approach for Accurate Portraying of Widespread Multifunctional Aspects ofFrontiers in microbiology · 2017Review
- High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer.Virchows Archiv : an international journal of pathology · 2017Article
- Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.Advances in experimental medicine and biology · 2017Review
- FXR1: Linking cellular quiescence, immune genes and cancer.Cell cycle (Georgetown, Tex.) · 2016Article
- Regulation of monocyte induced cell migration by the RNA binding protein, FXR1.Cell cycle (Georgetown, Tex.) · 2016Article
- Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay.Molecular & cellular proteomics : MCP · 2016Article
- Dysregulation and restoration of translational homeostasis in fragile X syndrome.Nature reviews. Neuroscience · 2015Review
- Review
- eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei.RNA (New York, N.Y.) · 2014Article
- mRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach.BMC systems biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
mRNA translation, a highly coordinated affair involving many proteins and RNAs, is generally divided into three steps: initiation, elongation, and termination. Each of these steps serves as a point of regulation to control the amount of protein that is produced. The protein 4E-HP has recently been shown to disrupt recruitment of the translation initiation complex by directly binding the 5' cap of cellular mRNAs. Recent work has shown elongation rates are probably altered during mitosis and certain types of synaptic transmission. Other work has shown premature termination of mRNAs lacking stop codons appears to repress their translation. Together, these studies highlight the importance of translational control in diverse processes such as development, cancer, and synaptic plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.