ArticleFungal genetics and biology : FG & B
Structural and functional properties of the Trichosporon asahii glucuronoxylomannan.
Article in Fungal genetics and biology : FG & B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Relationship Between Onychomycosis and HIV: A Systematic Review.Journal of fungi (Basel, Switzerland) · 2026Review
- Innovative mycosynthesis of chitosan nanoparticles via bionanofactory Penicillium crustosum: optimization, characterization, and application against building-deteriorating fungus, Trichosporon asahii.Biotechnology for biofuels and bioproducts · 2026Article
- In Silico Analysis and Expression Profiling of Adhesin-Like Flocculins in Trichosporon asahii.Mycopathologia · 2026Article
- Characterization of Virulence Factors, Cellular Stress Response, and Antifungal Susceptibility Testing ofJournal of fungi (Basel, Switzerland) · 2025Article
- Host-membrane lipid composition controlsFrontiers in immunology · 2025Article
- Purification, structural characterization, and bioactive properties of exopolysaccharides fromFrontiers in bioengineering and biotechnology · 2024Article
- More complicated than it seems: The diversity of cryptococcal glucuronoxylomannan.PLoS pathogens · 2023Article
- Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhu GM-CSF) as Adjuvant Therapy for Invasive Fungal Diseases.Open forum infectious diseases · 2022Article
- Monoclonal Antibodies against Cell Wall Chitooligomers as Accessory Tools for the Control of Cryptococcosis.Antimicrobial agents and chemotherapy · 2021Article
- Article
- A Novel, Inexpensive In-House Immunochromatographic Strip Test for Cryptococcosis Based on the Cryptococcal Glucuronoxylomannan Specific Monoclonal Antibody 18B7.Diagnostics (Basel, Switzerland) · 2021Article
- Structure and Foaming Properties of Viscous Exopolysaccharides from a Wild Grape-Associated Basidiomycetous YeastJournal of microbiology and biotechnology · 2020Article
- Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans.Fungal genetics and biology : FG & B · 2020Article
- Article
- The Cell Biology of theFrontiers in cellular and infection microbiology · 2017Review
- A critical role of Dectin-1 in hypersensitivity pneumonitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- On and Under the Skin: Emerging Basidiomycetous Yeast Infections Caused by Trichosporon Species.PLoS pathogens · 2015Review
- The vacuolar-sorting protein Snf7 is required for export of virulence determinants in members of the Cryptococcus neoformans complex.Scientific reports · 2014Article
- L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon.FEMS yeast research · 2014Article
- Multiple species of Trichosporon produce biofilms highly resistant to triazoles and amphotericin B.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The virulence attributes of Trichosporon asahii are virtually unknown, despite its growing relevance as causative agent of superficial and invasive diseases in humans. Glucuronoxylomannan (GXM) is a well described virulence factor of pathogenic species in the Cryptococcus genus. GXM is also produced by species of the Trichosporon genus, and both polysaccharides share antigenic determinants, but unlike cryptococcal GXM, relatively little work has been done on trichosporal GXMs. In this study, we analyzed structural and functional aspects of GXM produced by T. asahii and compared them to the properties of the cryptococcal polysaccharide. Trichosporal and cryptococcal GXM shared antigenic reactivity, but the former polysaccharide had smaller effective diameter and negative charge. GXM anchoring to the cell wall was perturbed by dimethylsulfoxide and required interactions of chitin-derived oligomers with the polysaccharide. GXM from T. asahii supernatants are incorporated by acapsular mutants of Cryptococcus neoformans, which renders these cells more resistant to phagocytosis by mouse macrophages. In summary, our results establish that despite similarities in cell wall anchoring, antigenic and antiphagocytic properties, trichosporal and cryptococcal GXMs manifest major structural differences that may directly affect polysaccharide assembly at the fungal surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.