ArticleCurrent biology : CB2009
Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed.
- Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development.Communications biology · 2026Article
- Article
- Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mutual suppression between mutations in the Dictyostelium Greenbeard pathway restores wild-type development.BMC genomics · 2025Article
- Testing the coordination hypothesis: incompatibilities in aggregative development of an experimentally evolved social amoeba.Evolution letters · 2025Article
- Going against the family: Perturbation of a greenbeard pathway leads to falsebeard cheating.iScience · 2024Article
- The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum.Nature communications · 2024Article
- In the social amoebaPeerJ · 2024Article
- Reduced social function in experimentally evolvedProceedings. Biological sciences · 2023Article
- Host-parasite coevolution and the stability of genetic kin recognition.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Developmental constraints enforce altruism and avert the tragedy of the commons in a social microbe.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Multiple social encounters can eliminate Crozier's paradox and stabilise genetic kin recognition.Nature communications · 2022Article
- The evolution of extraordinary self-sacrifice.Scientific reports · 2022Article
- Trogocytosis in Unicellular Eukaryotes.Cells · 2021Review
- Transcriptional milestones inGenome research · 2021Article
- Cyclic AMP is dispensable for allorecognition in Dictyostelium cells overexpressing PKA-C.Journal of cell science · 2021Article
- Review
- Search for MHC/TCR-Like Systems in Living Organisms.Frontiers in immunology · 2021Article
- WildEcology and evolution · 2020Article
- Social Chemical Communication Determines Recovery From L1 Arrest via DAF-16 Activation.Frontiers in cell and developmental biology · 2020Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Self and kin discrimination are observed in most kingdoms of life and are mediated by highly polymorphic plasma membrane proteins. Sequence polymorphism, which is essential for effective recognition, is maintained by balancing selection. Dictyostelium discoideum are social amoebas that propagate as unicellular organisms but aggregate upon starvation and form fruiting bodies with viable spores and dead stalk cells. Aggregative development exposes Dictyostelium to the perils of chimerism, including cheating, which raises questions about how the victims survive in nature and how social cooperation persists. Dictyostelids can minimize the cost of chimerism by preferential cooperation with kin, but the mechanisms of kin discrimination are largely unknown. Dictyostelium lag genes encode transmembrane proteins with multiple immunoglobulin (Ig) repeats that participate in cell adhesion and signaling. Here, we describe their role in kin discrimination. We show that lagB1 and lagC1 are highly polymorphic in natural populations and that their sequence dissimilarity correlates well with wild-strain segregation. Deleting lagB1 and lagC1 results in strain segregation in chimeras with wild-type cells, whereas elimination of the nearly invariant homolog lagD1 has no such consequences. These findings reveal an early evolutionary origin of kin discrimination and provide insight into the mechanism of social recognition and immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.