ArticleNeuroscience2009
Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.
Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRα3.bioRxiv : the preprint server for biology · 2023Article
- Review
- Cutaneous TRPV1Cell · 2019Article
- The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells.Frontiers in molecular neuroscience · 2017Review
- TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms.Molecular pain · 2014Article
- Presynaptic modulation of spinal nociceptive transmission by glial cell line-derived neurotrophic factor (GDNF).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons.Molecular pain · 2014Article
- Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma.Cancer research · 2014Article
- Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- TRPV1 and TRPA1 function and modulation are target tissue dependent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation.Gastroenterology · 2011Article
- Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization.Molecular pain · 2011Article
- Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Article
- Distribution of artemin and GFRalpha3 labeled nerve fibers in the dura mater of rat: artemin and GFRalpha3 in the dura.Headache · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are a group of peptides that have been implicated as important factors in inflammation, since they are released in increased amounts during inflammation and induce thermal hyperalgesia upon injection. Mouse isolated sensory neurons in culture and freshly dissociated spinal cord slices were used to examine the enhancement in stimulated-release of the neuropeptide, calcitonin gene-related peptide (CGRP), as a measure of sensitization. Exposure of isolated sensory neurons in culture to GDNF, neurturin, and artemin enhanced the capsaicin-stimulated release of immunoreactive calcitonin gene-related peptide (iCGRP) two- to threefold, but did not increase potassium-stimulated release of iCGRP. A similar profile of sensitization was observed in freshly dissociated spinal cord slices. Persephin, another member of the GFL family thought to be important in development, was unable to induce an enhancement in the release of iCGRP. These results demonstrate that specific GFLs are important mediators affecting sensory neuronal sensitivity, likely through modulation of the capsaicin receptor. The sensitization of sensory neurons during inflammation, and the pain and neurogenic inflammation resulting from this sensitization, may be due in part to the effects of these selected GFLs.
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Registered trials
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