ArticleJournal of proteome research2009
Immunologic glycosphingolipidomics and NKT cell development in mouse thymus.
Article in Journal of proteome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3.RSC advances · 2022Article
- New insights into iNKT cells and their roles in liver diseases.Frontiers in immunology · 2022Review
- Role of Globotriaosylceramide in Physiology and Pathology.Frontiers in molecular biosciences · 2022Review
- β-Glucosylceramide From Allergic Mothers Enhances Offspring Responsiveness to Allergen.Frontiers in allergy · 2021Article
- Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review.Current diabetes reports · 2020Review
- The Role of Glycosphingolipids in Immune Cell Functions.Frontiers in immunology · 2019Review
- Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling.Cell research · 2019Article
- Mass spectrometric analysis of glycosphingolipid antigens.Journal of visualized experiments : JoVE · 2013Article
- Invariant natural killer T cells as sensors and managers of inflammation.Trends in immunology · 2013Review
- Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection.Advances in experimental medicine and biology · 2013Review
- Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology.Journal of carbohydrate chemistry · 2013Article
- Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients.Glycobiology · 2012Article
- Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals.Nature immunology · 2011Article
- NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors.Journal of immunology (Baltimore, Md. : 1950) · 2011Review
- Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.Frontiers in bioscience (Scholar edition) · 2011Review
- Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains.Journal of lipid research · 2011Article
- Article
- Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis.Glycoconjugate journal · 2010Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Invariant NKT cells are a hybrid cell type of Natural Killer cells and T cells, whose development is dependent on thymic positive selection mediated by double positive thymocytes through their recognition of natural ligands presented by CD1d, a nonpolymorphic, non-MHC, MHC-like antigen presenting molecule. Genetic evidence suggested that beta-glucosylceramide derived glycosphingolipids (GSLs) are natural ligands for NKT cells. N-butyldeoxygalactonojirimycin (NB-DGJ), a drug that specifically inhibits the glucosylceramide synthase, inhibits the endogenous ligands for NKT cells. Furthermore, we and others have found a beta-linked glycosphingolipid, isoglobotriaosylceramide (iGb3), is a stimulatory NKT ligand. The iGb3 synthase knockout mice have a normal NKT development and function, indicating that other ligands exist and remain to be identified. In this study, we have performed a glycosphingolipidomics study of mouse thymus, and studied mice mutants which are deficient in beta-hexosaminidase b or alpha-galactosidase A, two glycosidases that are up- and downstream agents of iGb3 turnover, respectively. Our mass spectrometry methods generated a first database for glycosphingolipids expressed in mouse thymus, which are specifically regulated by rate-limiting glycosidases. Among the identified thymic glycosphingolipids, only iGb3 is a stimulatory ligand for NKT cells, suggesting that large-scale fractionation, enrichment and characterization of minor species of glycosphingolipids are necessary for identifying additional ligands for NKT cells. Our results also provide early insights into cellular lipidomics studies, with a specific focus on the important immunological functions of glycosphingolipids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.