ArticleGenetics, selection, evolution : GSE2009
Casein haplotypes and their association with milk production traits in Norwegian Red cattle.
Article in Genetics, selection, evolution : GSE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 101 citations in OpenAlex.
- β-Casein Polymorphism in Serbian Holstein-Friesian and Busha Cattle and Its Association with Milk Production Traits.Animals : an open access journal from MDPI · 2026Article
- Comparative Single-Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Effects of Different Cow-Milk Beta-Caseins on the Gut-Brain Axis: A Narrative Review of Preclinical, Animal, and Human Studies.Nutrition reviews · 2025Review
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- Validation ofAnimals : an open access journal from MDPI · 2024Article
- Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review.World journal of clinical pediatrics · 2024Article
- Associations of bovine beta-casein and kappa-casein genotypes with genomic merit in Holstein Friesian cattle.Archives animal breeding · 2024Article
- The variation in the beta-casein genotypes and its effect on milk yield and genomic values in Holstein-Friesian cows.Animal biotechnology · 2023Article
- Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.Animals : an open access journal from MDPI · 2023Review
- Does a Little Difference Make a Big Difference? Bovine β-Casein A1 and A2 Variants and Human Health-An Update.International journal of molecular sciences · 2022Review
- Demographic pattern of A1/A2 beta casein variants indicates conservation of A2 type haplotype across native cattle breeds (3 Biotech · 2022Article
- Worldwide Research Trends on Milk Containing Only A2 β-Casein: A Bibliometric Study.Animals : an open access journal from MDPI · 2022Article
- Candidate Genes and Their Expressions Involved in the Regulation of Milk and Meat Production and Quality in Goats (Animals : an open access journal from MDPI · 2022Review
- First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants.Genes · 2021Article
- Casein (CSN) gene variants and parity affect the milk protein traits in crossbred (Bos taurus x Bos indicus) cows in sub-tropical climate.Tropical animal health and production · 2021Article
- Comparative Genomics, Evolutionary and Gene Regulatory Regions Analysis of Casein Gene Family inFrontiers in genetics · 2021Article
- Review
- Polymorphism and molecular characteristics of theArchives animal breeding · 2020Article
- Association ofArchives animal breeding · 2020Article
- 5'-flanking variants of equine casein genes (CSN1S1, CSN1S2, CSN2, CSN3) and their relationship with gene expression and milk composition.Journal of applied genetics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high resolution SNP map was constructed for the bovine casein region to identify haplotype structures and study associations with milk traits in Norwegian Red cattle. Our analyses suggest separation of the casein cluster into two haplotype blocks, one consisting of the CSN1S1, CSN2 and CSN1S2 genes and another one consisting of the CSN3 gene. Highly significant associations with both protein and milk yield were found for both single SNPs and haplotypes within the CSN1S1-CSN2-CSN1S2 haplotype block. In contrast, no significant association was found for single SNPs or haplotypes within the CSN3 block. Our results point towards CSN2 and CSN1S2 as the most likely loci harbouring the underlying causative DNA variation. In our study, the most significant results were found for the SNP CSN2_67 with the C allele consistently associated with both higher protein and milk yields. CSN2_67 calls a C to an A substitution at codon 67 in beta-casein gene resulting in histidine replacing proline in the amino acid sequence. This polymorphism determines the protein variants A1/B (CSN2_67 A allele) versus A2/A3 (CSN2_67 C allele). Other studies have suggested that a high consumption of A1/B milk may affect human health by increasing the risk of diabetes and heart diseases. Altogether these results argue for an increase in the frequency of the CSN2_67 C allele or haplotypes containing this allele in the Norwegian Red cattle population by selective breeding.
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