ArticleGenetics, selection, evolution : GSE2009
Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology.
Article in Genetics, selection, evolution : GSE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Scanning the genomes of parents for imprinted loci acting in their un-genotyped progeny.Scientific reports · 2019Article
- Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat.G3 (Bethesda, Md.) · 2018Article
- Allele-Specific Transcriptome and Methylome Analysis Reveals Stable Inheritance and Cis-Regulation of DNA Methylation in Nasonia.PLoS biology · 2016Article
- Transcriptome-wide investigation of genomic imprinting in chicken.Nucleic acids research · 2014Article
- Quantitative trait loci affecting response to crowding stress in an F(2) generation of rainbow trout produced through phenotypic selection.Marine biotechnology (New York, N.Y.) · 2013Article
- Epigenetics and phenotypic variability: some interesting insights from birds.Genetics, selection, evolution : GSE · 2013Review
- Diet-dependent genetic and genomic imprinting effects on obesity in mice.Obesity (Silver Spring, Md.) · 2011Article
- Joint QTL analysis of three connected F2-crosses in pigs.Genetics, selection, evolution : GSE · 2010Article
- Matrisibs, patrisibs, and the evolution of imprinting on autosomes and sex chromosomes.The American naturalist · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionVariance component QTL methodology was used to analyse three candidate regions on chicken chromosomes 1, 4 and 5 for dominant and parent-of-origin QTL effects. Data were available for bodyweight and conformation score measured at 40 days from a two-generation commercial broiler dam line. One hundred dams were nested in 46 sires with phenotypes and genotypes on 2708 offspring. Linear models were constructed to simultaneously estimate fixed, polygenic and QTL effects. Different genetic models were compared using likelihood ratio test statistics derived from the comparison of full with reduced or null models. Empirical thresholds were derived by permutation analysis.
resultsDominant QTL were found for bodyweight on chicken chromosome 4 and for bodyweight and conformation score on chicken chromosome 5. Suggestive evidence for a maternally expressed QTL for bodyweight and conformation score was found on chromosome 1 in a region corresponding to orthologous imprinted regions in the human and mouse.
conclusionInitial results suggest that variance component analysis can be applied within commercial populations for the direct detection of segregating dominant and parent of origin effects.
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