ArticleRespiratory research2009
Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.
Article in Respiratory research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of air quality guidelines on COPD sufferers.International journal of chronic obstructive pulmonary disease · 2016Pooled it
- Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls.Molecular biology reports · 2015Pooled it
- Importance of hedgehog interacting protein and other lung function genes in asthma.The Journal of allergy and clinical immunology · 2011Pooled it
- MMP12, lung function, and COPD in high-risk populations.The New England journal of medicine · 2009Trial
- Relationship Between Proteinase with a Disintegrin and a Metalloproteinase Domain-9 (ADAM9), Inflammation, Airway Remodeling, and Emphysema in COPD Patients.International journal of chronic obstructive pulmonary disease · 2020Article
- Power and Sample Size Calculations for Genetic Association Studies in the Presence of Genetic Model Misspecification.Human heredity · 2019Article
- Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.American journal of respiratory and critical care medicine · 2017Article
- Article
- Genetic polymorphism and chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017Review
- Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD.BMC pulmonary medicine · 2014Article
- Association of ADAM33 gene polymorphisms with allergic asthma.Iranian journal of basic medical sciences · 2014Article
- Gene polymorphisms and chronic obstructive pulmonary disease.Journal of cellular and molecular medicine · 2014Article
- Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.Biomedical reports · 2013Article
- Article
- Power of a reproducing kernel-based method for testing the joint effect of a set of single-nucleotide polymorphisms.Genetica · 2012Article
- Genetics of asthma susceptibility and severity.Clinics in chest medicine · 2012Review
- Genome-wide association study of lung function decline in adults with and without asthma.The Journal of allergy and clinical immunology · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- Significance of bioinformatics in research of chronic obstructive pulmonary disease.Journal of clinical bioinformatics · 2011Article
- Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China.Molecular biology reports · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVariation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however, has not been investigated in the population susceptible to COPD; long term tobacco smokers. We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers.
methodsCaucasian subjects, at least 50 year old, who smoked >or= 20 pack-years (n = 880) were genotyped for 25 single nucleotide polymorphisms (SNPs) in ADAM33. COPD was defined as an FEV1/FVC ratio < 70% and percent-predicted (pp)FEV1 < 75% (n = 287). The control group had an FEV1/FVC ratio >or= 70% and ppFEV(1) >or= 80% (n = 311) despite >or= 20 pack years of smoking. Logistic and linear regressions were used for the analysis. Age, sex, and smoking status were considered as potential confounders.
resultsFive SNPs in ADAM33 were associated with COPD (Q-1, intronic: p < 0.003; S1, Ile --> Val: p < 0.003; S2, Gly --> Gly: p < 0.04; V-1 intronic: p < 0.002; V4, in 3' untranslated region: p < 0.007). Q-1, S1 and V-1 were also associated with ppFEV1, FEV1/FVC ratio and ppFEF25-75 (p values 0.001 - 0.02). S2 was associated with FEV1/FVC ratio (p < 0.05). The association between S1 and residual volume revealed a trend toward significance (p value < 0.07). Linkage disequilibrium and haplotype analyses suggested that S1 had the strongest degree of association with COPD and pulmonary function abnormalities.
conclusionFive SNPs in ADAM33 were associated with COPD and lung function in long-term smokers. Functional studies will be needed to evaluate the biologic significance of these polymorphisms in the pathogenesis of COPD.
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