ArticleGenetics, selection, evolution : GSE2009
Detecting selection-induced departures from Hardy-Weinberg proportions.
Article in Genetics, selection, evolution : GSE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Sex-specific effects ofVeterinary world · 2026Article
- Commonly used Hardy-Weinberg equilibrium filtering schemes impact population structure inferences using RADseq data.Molecular ecology resources · 2022Article
- Discrepancies of RET gene and risk of differentiated thyroid carcinoma.Cancer biomarkers : section A of Disease markers · 2022Article
- Genetic diversity and population structure in divergent German cattle selection lines on the basis of milk protein polymorphisms.Archives animal breeding · 2021Article
- The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics.Evolution letters · 2020Article
- Predicting the strength of urban-rural clines in a Mendelian polymorphism along a latitudinal gradient.Evolution letters · 2020Article
- Article
- microRNA-27a and microRNA-146a SNP in cerebral malaria.Molecular genetics & genomic medicine · 2019Article
- Signatures of selection in mammalian clock genes with coding trinucleotide repeats: Implications for studying the genomics of high-pace adaptation.Ecology and evolution · 2017Article
- Article
- Association between immunoglobulin GM and KM genotypes and placental malaria in HIV-1 negative and positive women in western Kenya.PloS one · 2013Article
- Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing.Immunogenetics · 2012Article
- No association of catechol-O-methyltransferase polymorphisms with schizophrenia in the Han Chinese population.Genetic testing and molecular biomarkers · 2012Article
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Funding
Abstract
Viability selection influences the genotypic contexts of alleles and leads to quantifiable departures from Hardy-Weinberg proportions. One measure of these departures is Wright's inbreeding coefficient (F), where observed heterozygosity is compared with expected heterozygosity. Here, I extend population genetics theory to describe post-selection genotype frequencies in terms of post-selection allele frequencies and fitness dominance. The resulting equations correspond to non-equilibrium populations, allowing the following questions to be addressed: When selection is present, how large a sample size is needed to detect significant departures from Hardy-Weinberg? How do selection-induced departures from Hardy-Weinberg vary with allele frequencies and levels of fitness dominance? For realistic selection coefficients, large sample sizes are required and departures from Hardy-Weinberg proportions are small.
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