ArticleGenetics, selection, evolution : GSE2009
Large-scale association study for structural soundness and leg locomotion traits in the pig.
Article in Genetics, selection, evolution : GSE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.Current issues in molecular biology · 2026Article
- Genetic parameters for image-based estimations of swine feet and leg conformation traits.Journal of animal science · 2025Article
- Genomic analysis of mobility measures on 5-month-old gilts associated with structural soundness.Journal of animal science · 2025Article
- Deep learning based landmark detection for measuring hock and knee angles in sows.Translational animal science · 2024Article
- Genetic diversity and population structure of six autochthonous pig breeds from Croatia, Serbia, and Slovenia.Genetics, selection, evolution : GSE · 2022Article
- Genome-Wide Detection of Genetic Loci and Candidate Genes for Body Conformation Traits in Duroc × Landrace × Yorkshire Crossbred Pigs.Frontiers in genetics · 2021Article
- Genome-wide comparative analysis ofbone morphogenetic proteins: genomic structure, phylogeny, and expression patterns in the golden pompano,Trachinotus ovatus(Linnaeus, 1758).Fish physiology and biochemistry · 2020Article
- A Genome-Wide Association Study on Feed Efficiency Related Traits in Landrace Pigs.Frontiers in genetics · 2020Article
- Evaluation of genotype quality parameters for SowPro90, a new genotyping array for swine1.Journal of animal science · 2019Article
- New world goat populations are a genetically diverse reservoir for future use.Scientific reports · 2019Article
- Objective evaluation of female feet and leg joint conformation at time of selection and post first parity in swine1.Journal of animal science · 2018Article
- Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs.Journal of applied genetics · 2018Article
- Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds.BMC genomics · 2013Article
- Articular osteochondrosis: a comparison of naturally-occurring human and animal disease.Osteoarthritis and cartilage · 2013Review
- KRT8, FAF1 and PTH1R gene polymorphisms are associated with leg weakness traits in pigs.Molecular biology reports · 2013Article
- Genome-Wide Association Identifies TBX5 as Candidate Gene for Osteochondrosis Providing a Functional Link to Cartilage Perfusion as Initial Factor.Frontiers in genetics · 2013Article
- A genome wide association study for backfat thickness in Italian Large White pigs highlights new regions affecting fat deposition including neuronal genes.BMC genomics · 2012Article
- Association and expression study of MMP3, TGFβ1 and COL10A1 as candidate genes for leg weakness-related traits in pigs.Molecular biology reports · 2012Article
- A functional mutation at position -155 in porcine APOE promoter affects gene expression.BMC genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentification and culling of replacement gilts with poor skeletal conformation and feet and leg (FL) unsoundness is an approach used to reduce sow culling and mortality rates in breeding stock. Few candidate genes related to soundness traits have been identified in the pig.
methodsIn this study, 2066 commercial females were scored for 17 traits describing body conformation and FL structure, and were used for association analyses. Genotyping of 121 SNPs derived from 95 genes was implemented using Sequenom's MassARRAY system.
resultsBased on the association results from single trait and principal components using mixed linear model analyses and false discovery rate testing, it was observed that APOE, BMP8, CALCR, COL1A2, COL9A1, DKFZ, FBN1 and VDBP were very highly significantly (P < 0.001) associated with body conformation traits. The genes ALOX5, BMP8, CALCR, OPG, OXTR and WNT16 were very highly significantly (P < 0.001) associated with FL structures, and APOE, CALCR, COL1A2, GNRHR, IHH, MTHFR and WNT16 were highly significantly (P < 0.01) associated with overall leg action. Strong linkage disequilibrium between CALCR and COL1A2 on SSC9 was detected, and haplotype -ACGACC- was highly significantly (P < 0.01) associated with overall leg action and several important FL soundness traits.
conclusionThe present findings provide a comprehensive list of candidate genes for further use in fine mapping and biological functional analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.