Evidence map›Paper›PMID 19284494›Full record

ArticleScandinavian journal of immunology2009

Placing regulatory T cells into global theories of immunity: an analysis of Cohn's challenge to integrity (Dembic).

C C Anderson

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In one paragraph

Article in Scandinavian journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. How do regulatory T cells work?Scandinavian journal of immunology · 2009
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

C C AndersonDepartment of Surgery, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. colinand@ualberta.ca

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In broadening the integrity model, Zlatko Dembic provided one of the few plausible explanations for the existence of regulatory T cells that has been postulated to date and at the same time highlighted deficiencies of the associative antigen recognition model. In defending the virtues of associative antigen recognition, Melvin Cohn has challenged the integrity model and the concept that regulatory T cells have a role in defining the specificity of immune responses. The critique of Cohn's analysis I present here suggests that a greater consideration of quantitative evolutionary constraints removes most of the challenges to integrity.

Indexed as

Models, ImmunologicalAnimalsHumansImmunityT-Lymphocytes, Regulatory

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.