ArticleJournal of Zhejiang University. Science. B2009
Expressions of cardiac sympathetic norepinephrine transporter and beta1-adrenergic receptor decreased in aged rats.
Article in Journal of Zhejiang University. Science. B, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Association between sleep duration and hypertension: Isfahan Healthy Heart Program, Iran.ARYA atherosclerosis · 2019Article
- Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation.NPJ aging and mechanisms of disease · 2017Article
- Heart failure with preserved ejection fraction in the elderly: scope of the problem.Journal of molecular and cellular cardiology · 2015Review
- Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe.Journal of Zhejiang University. Science. B · 2011Article
- An efficient method of addressing ectopic beats: new insight into data preprocessing of heart rate variability analysis.Journal of Zhejiang University. Science. B · 2011Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that the deterioration of communication between the sympathetic nervous system and cardiovascular system always accompanies the aging of human and animals. Cardiac sympathetic norepinephrine (NE) transporter (NET) on presynaptic membrane is a predominant component to eliminate released NE in the synaptic cleft and maintains the sensitivity of the beta-adrenergic receptor (beta-AR). In the present study, we investigated NET and beta1-AR mRNA levels and sympathetic nerve density in cardiac sympathetic ganglion and left ventricular myocardium in 2- and 16-month-old rats with Northern blot analysis and immunohistochemistry. The expression levels of NET mRNA, NET protein and beta1-AR mRNA in the ganglia or myocardia of 16-month-old rats were markedly reduced by 67%, 26%, and 43%, respectively, in comparison with those in 2-month-old rats. Our results also show that aging induces a strong decrease of the catecholaminergic nerve fiber density.
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