ArticleNeurochemical research2009
Cortical NMDA receptor expression in human chronic alcoholism: influence of the TaqIA allele of ANKK1.
Article in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.Biology · 2026Review
- Rare deleterious mutations are associated with disease in bipolar disorder families.Molecular psychiatry · 2017Article
- Understanding the Global Problem of Drug Addiction is a Challenge for IDARS Scientists.Current neuropharmacology · 2011Article
- Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration.Frontiers in psychiatry · 2011Article
- Electrically evoked synaptosomal amino acid transmitter release in human brain in alcohol misuse.Neuro-Signals · 2011Article
- Epigenetics and biomarkers in the staging of neuropsychiatric disorders.Neurotoxicity research · 2010Review
- Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys.Brain research · 2010Article
- Sex differences in NMDA receptor expression in human alcoholics.Alcohol and alcoholism (Oxford, Oxfordshire)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Real-time RT-PCR normalized to GAPDH was used to assay N-methyl-D-aspartate (NMDA) receptor NR1, NR2A and NR2B subunit mRNA in human autopsy cortex tissue from chronic alcoholics with and without comorbid cirrhosis of the liver and matched controls. Subunit expression was influenced by the subject's genotype. The TaqIA polymorphism selectively modulated NMDA receptor mean transcript expression in cirrhotic-alcoholic superior frontal cortex, in diametrically opposite ways in male and female subjects. Genetic make-up may differentially influence vulnerability to brain damage by altering the excitation: inhibition balance, particularly in alcoholics with comorbid cirrhosis of the liver. The TaqIA polymorphism occurs within the poorly characterised ankyrin-repeat containing kinase 1 (ANKK1) gene. Using PCR, ANKK1 mRNA transcript was detected in inferior temporal, occipital, superior frontal and primary motor cortex of control human brain. ANKK1 expression may mediate the influence of the TaqIA polymorphism on phenotype.
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Registered trials
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