Evidence map›Paper›PMID 19283409›Full record

ReviewParasitology research2009

Perspectives on the Trypanosoma cruzi-host cell receptor interactions.

Fernando Villalta, Julio Scharfstein, Anthony W Ashton, Kevin M Tyler, Fangxia Guan, Shankar Mukherjee, Maria F Lima, Sandra Alvarez, Louis M Weiss, Huan Huang and 2 more

Abstract readReview
In one paragraph

Review in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Mechanisms Associated withLife (Basel, Switzerland) · 2021
    Review
  5. Review
  6. Review
  7. Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fernando VillaltaDepartment of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN, USA. fvillalta@mmc.edu
Julio Scharfstein
Anthony W Ashton
Kevin M Tyler
Fangxia Guan
Shankar Mukherjee
Maria F Lima
Sandra Alvarez
Louis M Weiss
Huan Huang
Fabiana S Machado
Herbert B Tanowitz

Funding

Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Research Training in Cardivascular Biology at MeharryT32HL007737 · NHLBI · MEHARRY MEDICAL COLLEGE · PI MARTIN, PAMELA M · 1993 to 2025
$4.7M
MOLECULAR PARASITOLOGY TRAINING PROGRAMT32AI007281 · NIAID · MEHARRY MEDICAL COLLEGE · PI NDE, PIUS N · 1985 to 2025
$3.2M
T. cruzi: pathogenesis modulation by eicosanoidsR01AI076248 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI TANOWITZ, HERBERT BERNARD · 2008 to 2012
$2.3M
Molecular Mechanisms in Trypanosoma cruzi Cardiomyopathy in AIDSR01AI052739 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI TANOWITZ, HERBERT BERNARD · 2004 to 2008
$2.0M
Differentiation in T.cruzi:an emerging AIDS pathogenR01AI058893 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI HUANG, HUAN · 2005 to 2009
$1.8M
Molecular Analysis of Trypanosome InfectionSC1AI080580 · NIAID · MEHARRY MEDICAL COLLEGE · PI VILLALTA, FERNANDO · 2008 to 2010
$1.1M
Trypanosoma cruzi and AIDS: Role of the AdipocyteR21AI068538 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI TANOWITZ, HERBERT BERNARD · 2006 to 2007
$449k
NHLBI NIH HHS HL007737NHLBI NIH HHS T32 HL007737NIAID NIH HHS AI007281NIAID NIH HHS AI-052739NIAID NIH HHS AI-05893NIAID NIH HHS AI-076248NIAID NIH HHS AI080580NIAID NIH HHS R01 AI052739NIAID NIH HHS R01 AI058893NIAID NIH HHS R01 AI076248NIAID NIH HHS R21 AI068538NIAID NIH HHS R21AI068538NIAID NIH HHS SC1 AI080580NIAID NIH HHS T32 AI007281NIAID NIH HHS T-32-AI070117NIAID NIH HHS T32 AI070117
6 · The paper itself

Abstract

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

Indexed as

Host-Parasite InteractionsReceptors, Cell SurfaceAnimalsChagas DiseaseHumansTrypanosoma cruziReceptors, Cell Surface

Identifiers

PMID19283409
PMCPMC2696482

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.