ArticleUrological research2009
Primary cultures of renal proximal tubule cells derived from individuals with primary hyperoxaluria.
Article in Urological research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Exfoliated Kidney Cells from Urine for Early Diagnosis and Prognostication of CKD: The Way of the Future?International journal of molecular sciences · 2022Review
- Lithium induces mesenchymal-epithelial differentiation during human kidney development by activation of the Wnt signalling system.Cell death discovery · 2018Article
- Human Urine as a Noninvasive Source of Kidney Cells.Stem cells international · 2015Review
- A rapid and simple procedure for the establishment of human normal and cancer renal primary cell cultures from surgical specimens.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The primary hyperoxalurias, PH1 and PH2, are inherited disorders caused by deficiencies of alanine:glyoxylate aminotransferase and glyoxylate reductase, respectively. Mutations in either of these enzymes leads to endogenous oxalate overproduction primarily in the liver, but most pathological effects are exhibited in the kidney ultimately leading to end-stage renal failure and systemic oxalosis. To provide a non-invasive means of accessing kidney cells from individuals with primary hyperoxaluria, we have derived primary cultures of renal proximal tubule cells from the urine of these patients. The cells stain positively for the epithelial markers pan-cytokeratin and zonula occludens 1 and the proximal tubule marker gamma-glutamyl transpeptidase. Mutation analysis confirmed that the cultured cells had the same genotype as the leucocytes of the patients and also expressed glyoxylate reductase at the mRNA level, illustrating their potential value as a source of renal material from these individuals.
Indexed as
Identifiers
19283374What OpenQuestion holds
Registered trials
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