Evidence map›Paper›PMID 19283293›Full record

ArticleChemical communications (Cambridge, England)2009

Light-activation of gene function in mammalian cells via ribozymes.

Douglas D Young, R Aaron Garner, Jeffrey A Yoder, Alexander Deiters

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Optogenetic Tools for Regulating RNA Metabolism and Functions.Chembiochem : a European journal of chemical biology · 2024
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Intracellular light-activation of riboswitch activity.Chembiochem : a European journal of chemical biology · 2014
    Article
  10. Article
  11. Light-controlled synthetic gene circuits.Current opinion in chemical biology · 2012
    Review
  12. Article
  13. Review
  14. Article
  15. Principles and applications of the photochemical control of cellular processes.Chembiochem : a European journal of chemical biology · 2010
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Douglas D YoungDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
R Aaron Garner
Jeffrey A Yoder
Alexander Deiters

Funding

Switchable Systems for Spatio-Temporal Control of Gene Expression in ZebrafishR01GM079114 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DEITERS, ALEXANDER · 2007 to 2011
$1.6M
NIGMS NIH HHS GM079114NIGMS NIH HHS R01 GM079114
6 · The paper itself

Abstract

A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light.

Indexed as

Cell LineGene ExpressionHumansRNA, CatalyticRNA, MessengerToyocamycinUltraviolet Rayshammerhead ribozymeRNA, CatalyticRNA, MessengerToyocamycin

Identifiers

PMID19283293
PMCPMC3702056

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.