ArticlePLoS genetics2009
Multifactorial regulation of a hox target gene.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
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- Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression.Developmental neurobiology · 2022Article
- The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.The EMBO journal · 2017Article
- Hox targets and cellular functions.Scientifica · 2013Article
- The cis-regulatory code of Hox function in Drosophila.The EMBO journal · 2012Article
- In silico characterization of the neural alpha tubulin gene promoter of the sea urchin embryo Paracentrotus lividus by phylogenetic footprinting.Molecular biology reports · 2012Article
- Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in Drosophila.PLoS genetics · 2012Article
- Disentangling the many layers of eukaryotic transcriptional regulation.Annual review of genetics · 2012Review
- Activity of transcription factor JACKDAW is essential for SHR/SCR-dependent activation of SCARECROW and MAGPIE and is modulated by reciprocal interactions with MAGPIE, SCARECROW and SHORT ROOT.Plant molecular biology · 2011Article
- Insights into Hox protein function from a large scale combinatorial analysis of protein domains.PLoS genetics · 2011Article
- The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation.The Journal of investigative dermatology · 2011Article
- Mechanisms of transcription factor selectivity.Trends in genetics : TIG · 2010Review
- Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo.Development (Cambridge, England) · 2010Article
- Article
Corrections and comments
- Erratum issuedStein, Sokrates M A [corrected to Stein, M A Sokrates]
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox proteins play fundamental roles in controlling morphogenetic diversity along the anterior-posterior body axis of animals by regulating distinct sets of target genes. Within their rather broad expression domains, individual Hox proteins control cell diversification and pattern formation and consequently target gene expression in a highly localized manner, sometimes even only in a single cell. To achieve this high-regulatory specificity, it has been postulated that Hox proteins co-operate with other transcription factors to activate or repress their target genes in a highly context-specific manner in vivo. However, only a few of these factors have been identified. Here, we analyze the regulation of the cell death gene reaper (rpr) by the Hox protein Deformed (Dfd) and suggest that local activation of rpr expression in the anterior part of the maxillary segment is achieved through a combinatorial interaction of Dfd with at least eight functionally diverse transcriptional regulators on a minimal enhancer. It follows that context-dependent combinations of Hox proteins and other transcription factors on small, modular Hox response elements (HREs) could be responsible for the proper spatio-temporal expression of Hox targets. Thus, a large number of transcription factors are likely to be directly involved in Hox target gene regulation in vivo.
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Registered trials
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