ArticlePLoS computational biology2009
Mechanical network in titin immunoglobulin from force distribution analysis.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- Time-Dependent Voronoi Analysis of Amino Acid Side-Chain Packing in Simulations.Journal of computational chemistry · 2026Article
- GenUnfold: Rapidly Predict Protein Mechanical Unfolding Trajectory via a Physics-Guided Diffusion Model.Proceedings of machine learning research · 2026Article
- Mechanically weak and highly dynamic state of mechanosensitive titin Ig domains induced by proline isomerization.Nature communications · 2025Article
- Tuning Protein Hydrogel Mechanics through Modulation of Nanoscale Unfolding and Entanglement in Postgelation Relaxation.ACS nano · 2022Article
- Contribution of hydrophobic interactions to protein mechanical stability.Computational and structural biotechnology journal · 2022Article
- Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy.Biophysical journal · 2018Article
- The Work of Titin Protein Folding as a Major Driver in Muscle Contraction.Annual review of physiology · 2018Review
- Accessibility explains preferred thiol-disulfide isomerization in a protein domain.Scientific reports · 2017Article
- Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor.Biophysical journal · 2017Article
- Release of Entropic Spring Reveals Conformational Coupling Mechanism in the ABC Transporter BtuCD-F.Biophysical journal · 2016Article
- Some studies on generalized coordinate sets for polyatomic molecules.The Journal of chemical physics · 2015Article
- Mapping Mechanical Force Propagation through Biomolecular Complexes.Nano letters · 2015Article
- Geometry Dynamics of α -Helices in Different Class I Major Histocompatibility Complexes.Journal of immunology research · 2015Article
- Identification of allosteric disulfides from prestress analysis.Biophysical journal · 2014Article
- Calculation and visualization of atomistic mechanical stresses in nanomaterials and biomolecules.PloS one · 2014Article
- Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions.Ultramicroscopy · 2014Article
- Structure of giant muscle proteins.Frontiers in physiology · 2013Review
- Isopeptide bonds mechanically stabilize spy0128 in bacterial pili.Biophysical journal · 2013Article
- Time-resolved force distribution analysis.BMC biophysics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of mechanical force in cellular processes is increasingly revealed by single molecule experiments and simulations of force-induced transitions in proteins. How the applied force propagates within proteins determines their mechanical behavior yet remains largely unknown. We present a new method based on molecular dynamics simulations to disclose the distribution of strain in protein structures, here for the newly determined high-resolution crystal structure of I27, a titin immunoglobulin (IG) domain. We obtain a sparse, spatially connected, and highly anisotropic mechanical network. This allows us to detect load-bearing motifs composed of interstrand hydrogen bonds and hydrophobic core interactions, including parts distal to the site to which force was applied. The role of the force distribution pattern for mechanical stability is tested by in silico unfolding of I27 mutants. We then compare the observed force pattern to the sparse network of coevolved residues found in this family. We find a remarkable overlap, suggesting the force distribution to reflect constraints for the evolutionary design of mechanical resistance in the IG family. The force distribution analysis provides a molecular interpretation of coevolution and opens the road to the study of the mechanism of signal propagation in proteins in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.