ArticleThe Journal of investigative dermatology2009
Evaluation of the clonal origin of multiple primary melanomas using molecular profiling.
Article in The Journal of investigative dermatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Epidermotropic Metastatic Melanoma Presenting as Eruptive Primary Melanomas.Pigment cell & melanoma research · 2025Article
- Article
- Targeted sequencing identifies the mutational signature of double primary and metastatic malignancies: a case report.Diagnostic pathology · 2019Article
- Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases.JAMA dermatology · 2017Article
- USING SOMATIC MUTATION DATA TO TEST TUMORS FOR CLONAL RELATEDNESS.The annals of applied statistics · 2015Article
- Isolated limb infusion as a model to test new agents to treat metastatic melanoma.Journal of surgical oncology · 2014Review
- Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population.The British journal of dermatology · 2013Observational
- Integrative genomics with mediation analysis in a survival context.Computational and mathematical methods in medicine · 2013Article
- Testing clonality of three and more tumors using their loss of heterozygosity profiles.Statistical applications in genetics and molecular biology · 2012Review
- Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas.Annals of surgical oncology · 2012Article
- A strategy for distinguishing optimal cancer subtypes.International journal of cancer · 2011Article
- Evaluating cancer epidemiologic risk factors using multiple primary malignancies.Epidemiology (Cambridge, Mass.) · 2010Review
- Testing clonal relatedness of tumors using array comparative genomic hybridization: a statistical challenge.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Numerous investigations have been conducted using molecular profiling to evaluate the possible clonal origin of second malignancies in various cancer types. However, to date no study assessing clonality of multiple primaries has been conducted in melanoma. In this investigation using patients treated at a specialist melanoma treatment center, we compared the somatic mutational profiles of pairs of melanomas designated as independent on the basis of thorough assessment of their clinical and pathologic characteristics. We used a set of highly polymorphic genetic markers selected on the basis of their chromosomal positions and the frequencies of reported allelic losses at these genetic loci. Our statistical testing strategy showed no significant evidence of clonal origin of the two primaries in 17 of the 19 patients examined. The results suggest that most second melanomas designated as independent primary tumors on the basis of their clinicopathologic features are indeed independent occurrences of the disease, supporting the validity of the criteria used by experienced pathologists in distinguishing new primaries from metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.