ArticleCell cycle (Georgetown, Tex.)2009
Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation.
Article in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- The dual role of p63 in cancer.Frontiers in oncology · 2023Review
- Dual Role of the Alternative Reading Frame ARF Protein in Cancer.Biomolecules · 2019Review
- TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background.Frontiers in oncology · 2019Article
- Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα.Cell death & disease · 2018Article
- A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation.Cell death and differentiation · 2017Article
- Genetic analysis of teat number in pigs reveals some developmental pathways independent of vertebra number and several loci which only affect a specific side.Genetics, selection, evolution : GSE · 2017Article
- The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System.International journal of molecular sciences · 2016Review
- The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth.Oncogene · 2016Article
- FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.Human molecular genetics · 2015Article
- Dynamic Change in p63 Protein Expression during Implantation of Urothelial Cancer Clusters.Neoplasia (New York, N.Y.) · 2015Article
- Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells.PloS one · 2015Article
- Modeling AEC-New approaches to study rare genetic disorders.American journal of medical genetics. Part A · 2014Review
- Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs.International journal of molecular sciences · 2014Article
- Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases.Cell communication & adhesion · 2014Review
- Regulation of p63 protein stability via ubiquitin-proteasome pathway.BioMed research international · 2014Review
- Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63.The Journal of investigative dermatology · 2013Article
- Mimicking p14ARF phosphorylation influences its ability to restrain cell proliferation.PloS one · 2013Article
- The p63 protein isoform ΔNp63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes.The Journal of biological chemistry · 2012Article
- Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.PloS one · 2012Article
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8 authors at 2 institutions in 2 countries.
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Abstract
The epidermis is a stratified epithelium which develops depending on the transcription factor p63, a member of the p53 family of transcription factors. p63 is strongly expressed in the innermost basal layer where highly proliferative epithelial cells reside. p63 functions as a molecular switch that initiates epithelial stratification or cell fate determination while regulating proliferation and differentiation of developmentally mature keratinocytes. p63 acts upstream of Dlx3 homeobox gene in a transcriptional regulatory pathway relevant to ectodermal dysplasia. Here we show that Dlx3 triggers p63 protein degradation by a proteasome-dependent pathway. Mutant DeltaNp63alpha in which Threonine397 and Serine383 were replaced with Alanine as well as C-terminal truncated versions of DeltaNp63alpha are resistant to Dlx3-mediated degradation. Transient expression of Dlx3 is associated with Raf1 phosphorylation. Dlx3 is unable to promote p63 degradation in Raf1 depleted MEF cells or upon pharmacological knockdown of Raf1. Our data support a previously unrecognized role for Dlx3 in posttranslational regulation of DeltaNp63alpha protein level, a mechanism that may contribute to reduce the abundance of DeltaNp63alpha during differentiation of stratified epithelia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.