ArticleCell cycle (Georgetown, Tex.)2009
Reprogramming cell fates in the mammary microenvironment.
Article in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- SOX9 and SEMA7A regulate cell plasticity in the postpartum mammary gland with implications for breast cancer.bioRxiv : the preprint server for biology · 2026Article
- Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application.Journal of personalized medicine · 2022Review
- Intraductal Injections into the Mouse Mammary Gland.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo.Cells · 2019Article
- 3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels.Acta biomaterialia · 2019Article
- Potential application of cell reprogramming techniques for cancer research.Cellular and molecular life sciences : CMLS · 2019Review
- Hormone signaling requirements for the conversion of non-mammary mouse cells to mammary cell fate(s) in vivo.Journal of mammary gland biology and neoplasia · 2015Review
- Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells.Breast cancer research : BCR · 2014Article
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- Functional characterization of stem cell activity in the mouse mammary gland.Stem cell reviews and reports · 2011Review
- Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation.The EMBO journal · 2011Article
- Survival and engraftment of mouse embryonic stem cells in the mammary gland.In vitro cellular & developmental biology. Animal · 2011Article
- The normal microenvironment directs mammary gland development.Journal of mammary gland biology and neoplasia · 2010Review
- Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells.BMC cancer · 2010Article
- Reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation.PloS one · 2010Article
- Introduction: transplantation of the normal mammary gland: early evidence for a mammary stem cell.Journal of mammary gland biology and neoplasia · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The capacity of any portion of the murine mammary gland to produce a complete functional mammary outgrowth upon transplantation to an epithelium-divested fat pad is unaffected by the age or reproductive history of the donor. Likewise, through serial transplantations, no loss of potency is detected when compared to similar transplantations of the youngest mammary tissue tested. This demonstrates that stem cell activity is maintained intact throughout the lifetime of the animal despite aging and the repeated expansion and depletion of the mammary epithelium through multiple rounds of pregnancy, lactation and involution. These facts support the contention that mammary stem cells reside in protected tissue locales (niches), where their reproductive potency remains essentially unchanged through life. Disruption of the tissue, to produce dispersed cells results in the desecration of the protection afforded by the "niche" and leads to a reduced capacity of dispersed epithelial cells (in terms of the number transplanted) to recapitulate complete functional mammary structures. Our studies demonstrate that during the reformation of mammary stem cell niches by dispersed epithelial cells in the context of the intact epithelium-free mammary stroma, non-mammary cells may be sequestered and reprogrammed to perform mammary epithelial cell functions including those ascribed to mammary stem/progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.