ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2009
Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Distinct effects of aging and klotho deletion on the choroid plexus.GeroScience · 2026Article
- Serum PTH ≥ 40 pg/mL as a Marker of Bone Fragility and Vitamin D Deficiency in Periodontitis Patients: Biochemical, Densitometric and Genetic Evidence.Biomolecules · 2025Article
- Article
- Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice.Journal of clinical biochemistry and nutrition · 2018Article
- Histochemical Examination on Periodontal Tissues of Klotho-Deficient Mice Fed With Phosphate-Insufficient Diet.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Acute tumoral calcinosis due to severe hyperphosphatemia in a maintenance hemodialysis patient.CEN case reports · 2016Article
- [Disorders of calcium metabolism].Der Internist · 2014Article
- Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions.The Journal of clinical endocrinology and metabolism · 2014Article
- The role of Klotho in energy metabolism.Nature reviews. Endocrinology · 2012Review
- Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters.European journal of endocrinology · 2012Article
- Phosphate sensing.Advances in chronic kidney disease · 2011Review
- Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging.Molecular and cellular biochemistry · 2011Article
- Rediscovering vitamin D.The Libyan journal of medicine · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
alpha-Klotho was first identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. alpha-Klotho has been shown to participate in the regulation of parathyroid hormone secretion and trans-epithelial transport of Ca(2+) in the choroid plexus and kidney. alpha-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney. These suggest that alpha-Klotho is a key player that integrates a multi-step regulatory system of calcium and phosphate homeostasis. Collectively, the molecular function of alpha-Klotho reveals a new paradigm that may change current concepts in mineral homeostasis and give rise to new insights in this field.
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