ArticleMolecular endocrinology (Baltimore, Md.)2009
Oncogenic ras blocks the cAMP pathway and dedifferentiates thyroid cells via an impairment of pax8 transcriptional activity.
Article in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies.Cancer discovery · 2021Article
- β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation.Oncotarget · 2016Article
- Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Wnt4 inhibits cell motility induced by oncogenic Ras.Oncogene · 2013Article
- Article
- DARPP-32 is required for MAPK/ERK signaling in thyroid cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
A deranged differentiation is often a landmark of transformed cells. We used a thyroid cell line expressing an inducible Ras oncoprotein in order to study the hierarchy of molecular events leading to suppression of thyroid-specific gene expression. We find that, upon Ras activation, there is an immediate global down-regulation of thyroid differentiation, which is associated with an inhibition of the cAMP signaling pathway. We demonstrate that an unusual negative cross talk between Ras oncogene and the cAMP pathway induces inactivation of the transcription factor Pax8 that we propose as a crucial event in Ras-induced dedifferentiation.
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