ReviewJournal of the American College of Cardiology2009
Heart failure with normal left ventricular ejection fraction.
Review in Journal of the American College of Cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01053091 (Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure), which is not on this map. Cited by 90 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dapagliflozin improves cardiac function and reduces adverse events in myocardial infarction: a meta-analysis in diabetic and non-diabetic populations.Frontiers in endocrinology · 2025Pooled it
- Heart failure among Indigenous Australians: a systematic review.BMC cardiovascular disorders · 2012Pooled it
- Baseline characteristics of patients in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial.Circulation. Heart failure · 2013Trial
- Effect of ranolazine on left ventricular dyssynchrony in patients with coronary artery disease.The American journal of cardiology · 2012Trial
- Atherosclerotic renal artery stenosis is prevalent in cardiorenal patients but not associated with left ventricular function and myocardial fibrosis as assessed by cardiac magnetic resonance imaging.BMC cardiovascular disorders · 2012Trial
- Assessments of Wnt/JAK-STAT Signaling Pathway in Relation to Sfrp5 Among Patients with Cardiac Diseases.International journal of molecular sciences · 2025Article
- Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae.Cardiovascular research · 2025Article
- Hemodynamics in Left-Sided Cardiomyopathies.Reviews in cardiovascular medicine · 2024Review
- Effects of exercise training on cardiac output in subjects with heart failure with preserved ejection fraction (HFpEF) - a protocol for a systematic review and meta-analysis.Systematic reviews · 2024Article
- Agreement of ejection fraction measured by coronary computed tomography (CT) and cardiac ultrasound in evaluating patients with chronic heart failure: an observational comparative study.Quantitative imaging in medicine and surgery · 2024Article
- Post-exercise left atrial conduit strain predicted hemodynamic change in heart failure with preserved ejection fraction.European radiology · 2024Article
- Hypertensive response to exercise, hypertension and heart failure with preserved ejection fraction (HFpEF)-a continuum of disease?Wiener klinische Wochenschrift · 2023Review
- MapperPlus: Agnostic clustering of high-dimension data for precision medicine.PLOS digital health · 2023Article
- Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure.The Journal of general physiology · 2023Article
- Age-related increases in cardiac excitability, refractoriness and impulse conduction favor arrhythmogenesis in male rats.Pflugers Archiv : European journal of physiology · 2023Article
- Device-based percutaneous treatments to decompress the left atrium in heart failure with preserved ejection fraction.Heart failure reviews · 2023Review
- Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction.Cardiovascular therapeutics · 2023Review
- The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction.Circulation. Heart failure · 2023Article
- Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging.Theranostics · 2022Article
- High-Intensity Interval Training for Heart Failure Patients With Preserved Ejection Fraction (HIT-HF)-Rational and Design of a Prospective, Randomized, Controlled Trial.Frontiers in physiology · 2021Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is estimated that approximately 50% of the heart failure population has a normal left ventricular ejection fraction, a complex broadly referred to as heart failure with normal left ventricular ejection fraction (HFNEF). While these patients have been considered in epidemiologic studies and clinical trials to represent a single pool of patients, limited more detailed studies indicate that HFNEF patients are a very heterogeneous group, with a number of key pathophysiologic mechanisms. This review summarizes and critically analyzes available data on the pathophysiology of HFNEF, placing it into context with a recently developed diagnostic algorithm. We evaluate the utility of commonly applied echocardiographic measures and biomarkers and integrate mechanistic observations into potential future therapeutic directions.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.