ReviewThe Surgical clinics of North America2009
The stressed host response to infection: the disruptive signals and rhythms of systemic inflammation.
Review in The Surgical clinics of North America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Continuous enteral and parenteral feeding each reduces heart rate variability but differentially influences monocyte gene expression in humans.Shock (Augusta, Ga.) · 2012Trial
- Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.Critical care medicine · 2017Article
- Burn trauma disrupts circadian rhythms in rat liver.International journal of burns and trauma · 2016Article
- A Chemical Engineer's Perspective on Health and Disease.Computers & chemical engineering · 2014Article
- On heart rate variability and autonomic activity in homeostasis and in systemic inflammation.Mathematical biosciences · 2014Article
- Time-restricted feeding and the realignment of biological rhythms: translational opportunities and challenges.Journal of translational medicine · 2014Review
- Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver.BMC bioinformatics · 2014Article
- Predicting critical transitions in a model of systemic inflammation.Journal of theoretical biology · 2013Article
- Translational applications of evaluating physiologic variability in human endotoxemia.Journal of clinical monitoring and computing · 2013Review
- A Systems Engineering Perspective on Homeostasis and Disease.Frontiers in bioengineering and biotechnology · 2013Review
- Modeling physiologic variability in human endotoxemia.Critical reviews in biomedical engineering · 2012Article
- Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia.Physiological genomics · 2011Article
- A physiological model for autonomic heart rate regulation in human endotoxemia.Shock (Augusta, Ga.) · 2011Article
- Relationship of basal heart rate variability to in vivo cytokine responses after endotoxin exposure.Shock (Augusta, Ga.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The cognate signals from sterile or pathogen-induced sources converge on the same recognition or response pathways. In the surgical patient, a systemic response to infection most often occurs in the context of ongoing inflammatory stress. Such an inflammatory response is modulated initially by the magnitude of injury and by patient-specific (endogenous) factors, such as confounding illness, age, and genetic variation. Over an extended period of stress, treatmentrelated (exogenous) factors add unpredictability to host responses to subsequent challenges, such as acquired infection. The host response is discussed in the context of how existing sterile stressors may modify the response to acquired infection in surgical patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.