ArticlePharmacology, biochemistry, and behavior2009
Ethanol-mediated aversive learning as a function of locomotor activity in a novel environment in infant Sprague-Dawley rats.
Article in Pharmacology, biochemistry, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion.Developmental psychobiology · 2013Article
- The unconditioned stimulus pre-exposure effect in preweanling rats in taste aversion learning: role of the training context and injection cues.Developmental psychobiology · 2013Article
- Acetaldehyde reinforcement and motor reactivity in newborns with or without a prenatal history of alcohol exposure.Frontiers in behavioral neuroscience · 2013Article
- Early role of the κ opioid receptor in ethanol-induced reinforcement.Physiology & behavior · 2012Article
- Ontogenetic differences in sensitivity to LiCl- and amphetamine-induced taste avoidance in preweanling rats.Chemical senses · 2011Article
- A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats.Developmental psychobiology · 2010Article
- Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats.Behavioural brain research · 2010Article
- High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence.Developmental psychobiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Unlike adult heterogeneous rats, infant rats are sensitive to ethanol's locomotor stimulating effects. Susceptibility to this ethanol effect varies as a function of baseline locomotor activity levels. Infant rats with higher baseline activity levels are more sensitive to ethanol's stimulating effects than those with lower baseline activity levels. The present study was designed to analyze susceptibility to ethanol-induced motivational learning in subpopulations of infant heterogeneous rats that differ in baseline activity in a novel environment. On postnatal day 11 (PD 11) baseline locomotor activity was registered and infants were divided into high and low responders (HR, LR). In Experiment 1, pups were trained in a procedure of conditioned taste aversion employing ethanol (0.0, 0.5 or 2.5 g/kg) as unconditioned stimulus (US) and saccharin as conditioned stimulus. In Experiment 2 the same procedure was employed with LiCl (0.0, 0.25 or 0.5% of body weight of a 0.3 M LiCl solution) as US. HR were more resistant to the aversive effects of ethanol than LR while magnitude of LiCl-induced conditioned taste aversion was similar in HR and LR. These results suggest the possibility of early detection of subpopulations of rats with differential sensitivity to ethanol's effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.