ArticleDifferentiation; research in biological diversity2009
The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles.
Article in Differentiation; research in biological diversity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Article
- Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential.Clinical and translational medicine · 2024Review
- A Comprehensive Review of Mammalian Pigmentation: Paving the Way for Innovative Hair Colour-Changing Cosmetics.Biology · 2023Review
- Biology of melanocytes in mammals.Frontiers in cell and developmental biology · 2023Review
- Integrated Analysis of lncRNA and mRNA Reveals Novel Insights into Wool Bending in Zhongwei Goat.Animals : an open access journal from MDPI · 2021Article
- Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract.FEBS open bio · 2021Article
- Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration.Developmental biology · 2018Article
- Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy.The Journal of clinical investigation · 2018Article
- Spatiotemporal Labeling of Melanocytes in Mice.International journal of molecular sciences · 2018Review
- Celecoxib suppresses cutaneous squamous-cell carcinoma cell migration via inhibition of SDF1-induced endocytosis of CXCR4.OncoTargets and therapy · 2018Article
- PAX3 Promotes Cell Migration and CXCR4 Gene Expression in Neural Crest Cells.Journal of molecular neuroscience : MN · 2018Article
- Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.Cell stem cell · 2017Article
- Identification of the difference in the pathogenesis in heart failure arising from different etiologies using a microarray dataset.Clinics (Sao Paulo, Brazil) · 2017Article
- Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex.Biomaterials science · 2017Article
- Article
- Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF-1.Hippocampus · 2015Article
- Chicken trunk neural crest migration visualized with HNK1.Acta histochemica · 2015Article
- The melanocyte lineage in development and disease.Development (Cambridge, England) · 2015Review
- Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation.Experimental dermatology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mouse skin melanocytes originate from the neural crest and subsequently invade the epidermis and migrate into the hair follicles (HF) where they proliferate and differentiate. Here we demonstrate a role for the chemokine SDF-1/CXCL12 and its receptor CXCR4 in regulating the migration and positioning of melanoblasts during HF formation and cycling. CXCR4 expression by melanoblasts was upregulated during the anagen phase of the HF cycle. CXCR4-expressing cells in the HF also expressed the stem cell markers nestin and LEX, the neural crest marker SOX10 and the cell proliferation marker PCNA. SDF-1 was widely expressed along the path taken by migrating CXCR4-expressing cells in the outer root sheath (ORS), suggesting that SDF-1-mediated signaling might be required for the migration of CXCR4 cells. Skin sections from CXCR4-deficient mice, and skin explants treated with the CXCR4 antagonist AMD3100, contained melanoblasts abnormally concentrated in the epidermis, consistent with a defect in their migration. SDF-1 acted as a chemoattractant for FACS-sorted cells isolated from the anagen skin of CXCR4-EGFP transgenic mice in vitro, and AMD3100 inhibited the SDF-1-induced migratory response. Together, these data demonstrate an important role for SDF-1/CXCR4 signaling in directing the migration and positioning of melanoblasts in the HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.