ArticleThe Journal of infectious diseases2009
Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Tumor necrosis factor-α (TNF-α) -308G >a promoter polymorphism (rs1800629) promotes Asians in susceptibility to Plasmodium falciparum severe malaria: A meta-analysis.PLoS neglected tropical diseases · 2023Pooled it
- Polymorphisms in Lymphotoxin-Alpha as the "Missing Link" in Prognosticating Favourable Response to Omega-3 Supplementation for Dry Eye Disease: A Narrative Review.International journal of molecular sciences · 2023Review
- Impact ofFrontiers in genetics · 2023Article
- Review
- Risk score prediction model based on single nucleotide polymorphism for predicting malaria: a machine learning approach.BMC bioinformatics · 2022Article
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- TheInnate immunity · 2021Article
- Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction.Mediators of inflammation · 2020Article
- Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective.Frontiers in immunology · 2019Review
- Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population.Genes and immunity · 2017Article
- Malaria Host Candidate Genes Validated by Association With Current, Recent, and Historical Measures of Transmission Intensity.The Journal of infectious diseases · 2017Article
- Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB activation.Molecular medicine (Cambridge, Mass.) · 2016Article
- Environmental Correlation Analysis for Genes Associated with Protection against Malaria.Molecular biology and evolution · 2016Article
- Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection.Frontiers in immunology · 2016Review
- Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study.Malaria journal · 2015Article
- DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria.Malaria journal · 2014Article
- Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.PloS one · 2013Article
- Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.PloS one · 2013Article
- IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil.Malaria journal · 2012Article
- Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese.Genes and immunity · 2012Article
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 5 countries.
Funding
Abstract
The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving >10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF -238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.