ReviewInternational journal of chronic obstructive pulmonary disease2008
Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives.
Review in International journal of chronic obstructive pulmonary disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- A Multilevel Redox-Based Prognostic Model for Asthma Severity: From Genotype to Serum Biomarkers.Biomedicines · 2026Review
- 4-Hydroxynonenal, a Potential Biomarker for Lung Inflammatory Diseases.International journal of molecular sciences · 2026Review
- Uncovering the Role of Oxidative Imbalance in the Development and Progression of Bronchial Asthma.Oxidative medicine and cellular longevity · 2021Review
- Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer.iScience · 2020Article
- New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases.Journal of clinical medicine · 2020Review
- Mitochondrial Function in Peripheral Blood Mononuclear Cells (PBMC) Is Enhanced, Together with Increased Reactive Oxygen Species, in Severe Asthmatic Patients in Exacerbation.Journal of clinical medicine · 2019Article
- Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury.Molecular therapy. Nucleic acids · 2018Article
- Oxidative Stress Markers in Sputum.Oxidative medicine and cellular longevity · 2016Review
- Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury.Clinical science (London, England : 1979) · 2015Article
- A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases.Respiratory research · 2015Article
- COPD: balancing oxidants and antioxidants.International journal of chronic obstructive pulmonary disease · 2015Review
- Mechanistic impact of outdoor air pollution on asthma and allergic diseases.Journal of thoracic disease · 2015Review
- Oxidative stress-induced autophagy: role in pulmonary toxicity.Toxicology and applied pharmacology · 2014Review
- Oxidative stress and free radicals in COPD--implications and relevance for treatment.International journal of chronic obstructive pulmonary disease · 2014Review
- Biomarkers in chronic obstructive pulmonary disease: confusing or useful?International journal of chronic obstructive pulmonary disease · 2014Review
- Airway oxidative stress in chronic cough.Cough (London, England) · 2013Article
- Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.British journal of pharmacology · 2013Article
- Biomarkers in Exhaled Breath Condensate and Serum of Chronic Obstructive Pulmonary Disease and Non-Small-Cell Lung Cancer.International journal of chronic diseases · 2013Review
- Effects of dietary nutrients on volatile breath metabolites.Journal of nutritional science · 2013Article
- Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition.British journal of pharmacology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been claimed to be attributable to increased systemic and local oxidative stress. Detection of the oxidant burden and evaluation of their progression and phenotypes by oxidant biomarkers have proved challenging and difficult. A large number of asthmatics are cigarette smokers and smoke itself contains oxidants complicating further the use of oxidant biomarkers. One of the most widely used oxidant markers in asthma is exhaled nitric oxide (NO), which plays an important role in the pathogenesis of asthma and disease monitoring. Another oxidant marker that has been widely investigated in COPD is 8-isoprostane, but it is probably not capable of differentiating asthma from COPD, or even sensitive in the early assessment of these diseases. None of the current biomarkers have been shown to be better than exhaled NO in asthma. There is a need to identify new biomarkers for obstructive airway diseases, especially their differential diagnosis. A comprehensive evaluation of oxidant markers and their combinations will be presented in this review. In brief, it seems that additional analyses utilizing powerful tools such as genomics, metabolomics, lipidomics, and proteomics will be required to improve the specificity and sensitivity of the next generation of biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.