ArticleAmerican journal of human genetics1991
Expressed hypervariable polymorphism of apolipoprotein (a).
Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Atherosclerosis
Genetic Epidemiology of Coronary Heart Disease
Who cites it
35 citing papers in PubMed, 215 citations in OpenAlex.
- Inulin-enriched pasta affects lipid profile and Lp(a) concentrations in Italian young healthy male volunteers.European journal of nutrition · 2008Trial
- Lipoprotein(a) Response to Dietary Saturated Fat Reduction: Relationship to Apolipoprotein(a) Size Polymorphism in African Americans.Nutrients · 2025Article
- Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods.International journal of molecular sciences · 2023Review
- Lp(a)-Associated Oxidized Phospholipids in Healthy Black and White Participants in Relation to apo(a) Size, Age, and Family Structure.Journal of the American Heart Association · 2021Article
- PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability.Journal of the Endocrine Society · 2020Article
- Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families.Journal of lipid research · 2019Article
- Apolipoprotein(a) is the Product of a Pseudogene: Implications for the Pathophysiology of Lipoprotein(a).Cureus · 2018Review
- The roles of apo(a) size, phenotype, and dominance pattern in PCSK9-inhibition-induced reduction in Lp(a) with alirocumab.Journal of lipid research · 2017Article
- Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease.Indian journal of clinical biochemistry : IJCB · 2016Review
- High levels of inflammatory biomarkers are associated with increased allele-specific apolipoprotein(a) levels in African-Americans.The Journal of clinical endocrinology and metabolism · 2008Article
- Lipoprotein(a): an elusive cardiovascular risk factor.Arteriosclerosis, thrombosis, and vascular biology · 2004Review
- Effect of Nandrolone Decanoate on serum lipoprotein (a) and its isoforms in hemodialysis patients.Lipids in health and disease · 2004Article
- Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects.BMC cardiovascular disorders · 2003Article
- Array-based comparative genomic hybridization for the genomewide detection of submicroscopic chromosomal abnormalities.American journal of human genetics · 2003Article
- The role of lipoprotein[a] in atherosclerosis.Current atherosclerosis reports · 2000Review
- LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls.Indian journal of clinical biochemistry : IJCB · 1998Article
- Effect of sample storage on quantitation of lipoprotein(a) by an enzyme-linked immunosorbent assay.Lipids · 1996Article
- Serum lipoprotein(a) concentrations and apolipoprotein(a) phenotypes in the families of NIDDM patients.Diabetologia · 1995Article
- A pentanucleotide repeat polymorphism in the 5' control region of the apolipoprotein(a) gene is associated with lipoprotein(a) plasma concentrations in Caucasians.The Journal of clinical investigation · 1995Article
- Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.American journal of human genetics · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Elevated plasma lipoprotein (a) (LP(a] levels are an independent predictor of the development of premature atherosclerosis in humans. The LP(a) particle consists of two disulfide-linked proteins, apolipoprotein (APO) B and APO(a). The APO(a) is a highly glycosylated protein which carries the LP(a) antigen. Genetic polymorphism in the APO(a) molecule has been reported, and, depending on the sensitivity of the method used, 6-11 alleles at the APO(a) structural locus have been documented in the literature. In this investigation, we have used a high-resolution SDS-agarose electrophoresis method followed by immunoblotting to screen APO(a) polymorphism in 54 families with 130 offspring. This method identified a total of 23 different APO(a) isoforms, and their genetic basis was confirmed in families. In addition to the detectable products of 23 APO(a) alleles, the family data predict the existence of a "null" allele. Of the total 270 individuals tested, 209 (77.4%) revealed double-banded phenotypes and 61 (22.6%) revealed single-banded phenotypes. In the unrelated sample of 140 individuals, however, 114 (81.4%) and 26 (18.6%) had double- and single-banded phenotypes, respectively. When the segregation pattern of single-banded phenotypes in the unrelated sample was followed in families, only nine (6.4%) were found to be true homozygotes, and the remaining 17 (12.2%) were classified as heterozygotes for the null allele. Of the 276 possible phenotypes predicted for 23 alleles in a large population, we observed 115 (42%) phenotypes in our restricted sample. On the basis of our results from the family data, we hypothesize the existence of at least 24 alleles, including a null allele, at the APO(a) structural locus.(ABSTRACT TRUNCATED AT 250 WORDS)
Indexed as
Identifiers
1928089PMC1683273W2417365582What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.