ArticleDevelopmental neurobiology2009
The dependence on gp130 cytokines of axotomy induced neuropeptide expression in adult sympathetic neurons.
Article in Developmental neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Neural Mechanisms of Cancer Cachexia.Cancers · 2021Review
- Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration.Frontiers in neuroscience · 2019Article
- Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.Experimental neurology · 2017Article
- Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism.Experimental neurology · 2016Article
- The neuroimmunology of degeneration and regeneration in the peripheral nervous system.Neuroscience · 2015Review
- Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents.Cellular and molecular neurobiology · 2015Article
- Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A critical role for macrophages near axotomized neuronal cell bodies in stimulating nerve regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.Molecular and cellular neurosciences · 2013Article
- Article
- Cytokines that promote nerve regeneration.Experimental neurology · 2012Article
- Altered atrial neurotransmitter release in transgenic p75(-/-) and gp130 KO mice.Neuroscience letters · 2012Article
- Diet-induced obesity severely impairs myelinated aortic baroreceptor reflex responses.American journal of physiology. Heart and circulatory physiology · 2012Article
- Axonal transcription factors signal retrogradely in lesioned peripheral nerve.The EMBO journal · 2012Article
- Interleukin-17A increases neurite outgrowth from adult postganglionic sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Role of transcription factors in peripheral nerve regeneration.Frontiers in molecular neuroscience · 2012Article
- Activating transcription factor 3 and the nervous system.Frontiers in molecular neuroscience · 2012Article
- Cytokines inhibit norepinephrine transporter expression by decreasing Hand2.Molecular and cellular neurosciences · 2011Article
- Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms.Neuropeptides · 2011Article
- gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury.Frontiers in molecular neuroscience · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Adult peripheral neurons exhibit dramatic changes in gene expression after axonal injury, including changes in neuropeptide phenotype. For example, sympathetic neurons in the superior cervical ganglion (SCG) begin to express vasoactive intestinal peptide (VIP), galanin, pituitary adenylate cyclase activating polypeptide (PACAP), and cholecystokinin after axotomy. Before these changes, nonneuronal cells in the SCG begin to express leukemia inhibitory factor (LIF). When the effects of axotomy were compared in LIF-/- and wild-type mice, the increases in VIP and galanin expression were less in the former, though significant increases still occurred. LIF belongs to a family of cytokines with overlapping physiological effects and multimeric receptors containing the subunit gp130. Real-time PCR revealed large increases in the SCG after axotomy in mRNA for three members of this cytokine family, interleukin (IL)-6, IL-11, and LIF, with modest increases in oncostatin M, no changes in ciliary neurotrophic factor, and decreases in cardiotrophin-1. To explore the role of these cytokines, animals with selective elimination of the gp130 receptor in noradrenergic neurons were studied. No significant changes in mRNA levels for VIP, galanin, and PACAP were seen in axotomized ganglia from these mutant mice, while the increase in cholecystokinin was as large as that seen in wild-type mice. The data indicate that the inductions of VIP, galanin, and PACAP after axotomy are completely dependent on gp130 cytokines and that a second cytokine, in addition to LIF, is involved. The increase in cholecystokinin after axotomy, however, does not require the action of these cytokines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.