ArticlePurinergic signalling2009
Different properties of P2X(7) receptor in hippocampal and cortical astrocytes.
Article in Purinergic signalling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden.Purinergic signalling · 2024Article
- Extracellular vesicles released by microglia and macrophages carry endocannabinoids which foster oligodendrocyte differentiation.Frontiers in immunology · 2024Article
- Astrocyte adaptation in Alzheimer's disease: a focus on astrocytic P2X7R.Essays in biochemistry · 2023Review
- Astroglial Connexins in Neurodegenerative Diseases.Frontiers in molecular neuroscience · 2021Review
- Physiology of Astroglial Excitability.Function (Oxford, England) · 2020Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Potential role of P2X7R in esophageal squamous cell carcinoma proliferation.Purinergic signalling · 2017Article
- P2X7 receptors in body temperature, locomotor activity, and brain mRNA and lncRNA responses to sleep deprivation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Pathophysiology of astroglial purinergic signalling.Purinergic signalling · 2012Review
- Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism.The EMBO journal · 2012Article
- Using antibodies against P2Y and P2X receptors in purinergic signaling research.Purinergic signalling · 2012Article
- Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.Immunologic research · 2011Review
- Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.British journal of pharmacology · 2011Article
- 2', 3'-O-(4-benzoylbenzoyl)-ATP-mediated calcium signaling in rat glioma C6 cells: role of the P2Y(2) nucleotide receptor.Purinergic signalling · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P2X(7) receptor is a ligand-gated ion channel, which can induce the opening of large membrane pores. Here, we provide evidence that the receptor induces pore formation in astrocytes cultured from cortex, but not from the hippocampus. Furthermore, P2X(7) receptor activation promptly induces p38 mitogen-activated protein kinase (MAPK) phosphorylation in cortical but not in hippocampal astrocytes. Given the role of p38 MAPK activation in pore opening, these data suggest that defective coupling of the receptor to the enzyme could occur in hippocampal cultures. The different capabilities of the receptor to open membrane pores cause relevant functional consequences. Upon pore formation, caspase-1 is activated and pro-IL1-beta is cleaved and released extracellularly. The receptor stimulation does not result in interleukin-1beta secretion from hippocampal astrocytes, although the pro-cytokine is present in the cytosol of lipopolysaccharide-primed cultures. These results open the possibility that activation of P2X(7) receptors differently influences the neuroinflammatory processes in distinct brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.