ArticleInternal and emergency medicine2009
Molecular and clinical aspects of endothelial dysfunction in diabetes.
Article in Internal and emergency medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Acute effects of hyperinsulinemia and hyperglycemia on vascular inflammatory biomarkers and endothelial function in overweight and obese humans.American journal of physiology. Endocrinology and metabolism · 2015Trial
- Women with a history of gestational diabetes mellitus have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature.Experimental physiology · 2026Article
- Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction.Cardiovascular diabetology · 2022Article
- Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels.International journal of molecular sciences · 2018Review
- Coronary microvascular dysfunction in diabetes mellitus.The Journal of international medical research · 2017Review
- Occludin downregulation in high glucose is regulated by SSTRExperimental and therapeutic medicine · 2017Article
- Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction.BioMed research international · 2014Review
- Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice.Journal of diabetes research · 2014Review
- Insulin resistance, metabolic stress, and atherosclerosis.Frontiers in bioscience (Scholar edition) · 2012Review
- The role of the urologist in the prevention and early detection of cardiovascular disease.Arab journal of urology · 2011Review
- Molecular mechanisms of hyperglycemia and cardiovascular-related events in critically ill patients: rationale for the clinical benefits of insulin therapy.Clinical epidemiology · 2010Article
- Coronary spasm provocation with cold pressor test.Internal and emergency medicine · 2010Article
- Article
- Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.Reviews in endocrine & metabolic disorders · 2010Review
- Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.The American journal of pathology · 2009Article
- Metabolic syndrome in the pediatric population: a short overview.Pediatric reports · 2009Article
- Correlation between Transient Ischemic Dilation Index and Endothelin-1 Level in Patients with Type 2 Diabetes Mellitus.World journal of nuclear medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic patients have an increased risk for cardiovascular complications with respect to the general population. Micro- and macrovascular complications such as nephropathy, retinopathy, atherosclerosis, and coronary artery disease are usually preceded by endothelial dysfunction, a condition characterized by impaired vasorelaxation resulting from reduced bioavailability of the endothelial mediator nitric oxide (NO). Nitric oxide is among endothelial mediators released by endothelial cells in response to insulin stimulation. Therefore, metabolic abnormalities such as insulin resistance, dyslipidemia, compensatory hyperinsulinemia and overt hyperglycemia may all contribute to impaired NO bioavailability and abnormal vasodilatation in diabetic patients. Each of these alterations may trigger endothelial dysfunction by multiple intracellular mechanisms including accelerated formation of advanced glycolysis end products, activation of protein kinase C, increased pro-inflammatory signaling, and impaired sensitivity of the PI 3-kinase signaling pathways. This review outlines the most important mechanisms by which insulin takes part in physiological regulation of endothelial function. Abnormal insulin signaling in endothelium under diabetic conditions and patho-physiological consequences on cardiovascular homeostasis will also be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.