ArticleClinical oral investigations2010
Anabolic effect of intermittent PTH(1-34) on the local microenvironment during the late phase of periodontal repair in a rat model of tooth root resorption.
Article in Clinical oral investigations, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Reduced orthodontic tooth movement inJBMR plus · 2025Article
- LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling.International journal of oral science · 2023Article
- Impact of Orthodontic Forces on Plasma Levels of Markers of Bone Turnover and Inflammation in a Rat Model of Buccal Expansion.Frontiers in physiology · 2021Article
- Reduced Orthodontic Tooth Movement in Enpp1 Mutant Mice with Hypercementosis.Journal of dental research · 2018Article
- Mechanical loading influences the effects of bisphosphonates on human periodontal ligament fibroblasts.Clinical oral investigations · 2015Article
- In vivo differentiation of human periodontal ligament cells leads to formation of dental hard tissue.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2013Article
- Orthodontic and surgical management of cleidocranial dysplasia.Korean journal of orthodontics · 2013Article
- Regulation of macrophage migration and activity by high-mobility group box 1 protein released from periodontal ligament cells during orthodontically induced periodontal repair: an in vitro and in vivo experimental study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2013Article
- Potential role of high mobility group box protein 1 and intermittent PTH (1-34) in periodontal tissue repair following orthodontic tooth movement in rats.Clinical oral investigations · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the histological changes and possible effects of intermittent parathyroid hormone (PTH) (1-34) treatment during the early and late phase of periodontal repair in a rat model of tooth root resorption. In a total of 70 animals, which either received intermittent PTH(1-34) systemically or sham injections for up to 70 days after discontinuation of an orthodontic force, histological characteristics were correlated to time-dependent distinct expression patterns of osteoprotegerin and receptor activator of nuclear factor kappaB ligand by PDL cells in the former compression and tension side of tooth movement by means of immunohistochemistry and histomorphometrical analysis. The balance of these key regulators of bone remodeling was demonstrated to be shifted in favor of hard tissue repair by intermittent PTH administration, which was demonstrated to exert anabolic effects in several cell culture and animal experiments as well as in humans, in the late phase of repair. These data indicate a role for PDL cells as potent regulators of periodontal repair by modifying the local microenvironment and point to the anabolic potential of an intermittent PTH administration to support these reparative processes.
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