ReviewEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2009
An update on bone substitutes for spinal fusion.
Review in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03407560 (Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.), which is not on this map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy and safety of bone substitutes in lumbar spinal fusion: a systematic review and network meta-analysis of randomized controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Pooled it
- Spinal fusion procedures in the adult and young population: a systematic review on allogenic bone and synthetic grafts when compared to autologous bone.Journal of materials science. Materials in medicine · 2020Pooled it
- Efficacy of platelet-rich plasma in posterior lumbar interbody fusion: systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Pooled it
- A systematic review of comparative studies on bone graft alternatives for common spine fusion procedures.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2013Pooled it
- A prospective randomized comparison of PEEK cage containing calcium sulphate or demineralized bone matrix with autograft in anterior cervical interbody fusion.International orthopaedics · 2015Trial
- Platelet-rich plasma in mono-segmental posterior lumbar interbody fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2011Trial
- Long-Term Outcomes of Triple Cannulated Compression Screws Combined With Bone Graft Sleeve Parallel Implantation of DBM Crunch Internal Fixation for the Treatment of Femoral Neck Fractures in Middle-Aged and Young Adults.Orthopaedic surgery · 2025Article
- Ceramic substitutes, failure to achieve solid fusion in posterolateral instrumented fusion: a surgical and histological evaluation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- The benefit of antibiotic-combined Mg-hydroxyapatite bone graft substitute over autologous bone for surgical site infection prevention in posterolateral spinal fusion: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size.Bioactive materials · 2022Article
- Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study.Frontiers in bioengineering and biotechnology · 2022Article
- Allografts and Spinal Fusion.International journal of spine surgery · 2021Article
- rhBMP2 alone does not induce macrophage polarization towards an increased inflammatory response.Molecular immunology · 2020Article
- Interbody options in lumbar fusion.Journal of spine surgery (Hong Kong) · 2019Review
- [Lumbar fusion-Indications and techniques].Der Orthopade · 2019Review
- ISASS Recommendations and Coverage Criteria for Bone Graft Substitutes used in Spinal Surgery.International journal of spine surgery · 2018Article
- Modulating Bone Regeneration in Rabbit Condyle Defects with Three Surface-Structured Tricalcium Phosphate Ceramics.ACS biomaterials science & engineering · 2018Article
- Allograft Versus Demineralized Bone Matrix in Instrumented and Noninstrumented Lumbar Fusion: A Systematic Review.Global spine journal · 2018Review
- Efficacy of Platelet-Rich Plasma for Bone Fusion in Transforaminal Lumbar Interbody Fusion.Asian spine journal · 2018Article
- Soft tissue swelling incidence using demineralized bone matrix in the outpatient setting.World journal of orthopedics · 2017Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the current advances in spinal surgery, an understanding of the precise biological mechanism of each bone substitute is necessary for inducing successful spinal fusion. In this review, the categories of bone substitutes include allografts, ceramics, demineralized bone matrix, osteoinductive factors, autogenous platelet concentrate, mesenchymal stem cells, and gene therapy. Further, clinical studies have been evaluated by their levels of evidence in order to elucidate the precise effect of the bone substitute employed and to establish clinical guidance. This article will review both clinical studies based on evidence and basic research in current advances in order to avoid as far as possible any chances of failure in the future and to understand cellular biology in novel technologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.