ArticleHistochemistry and cell biology2009
Perivascular cells of the supraspinatus tendon express both tendon- and stem cell-related markers.
Article in Histochemistry and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 101 citations in OpenAlex.
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Article
- PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration.Nature communications · 2025Article
- Enhanced tenogenic potential of tendon-derived mesenchymal stem cells: transcriptomic profiling andFrontiers in cell and developmental biology · 2025Article
- Various Strategies of Tendon Stem/Progenitor Cell Reprogramming for Tendon Regeneration.International journal of molecular sciences · 2024Review
- Biological and Mechanical Factors and Epigenetic Regulation Involved in Tendon Healing.Stem cells international · 2023Review
- Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon.Bone & joint research · 2022Article
- Comparison of Tendon Development Versus Tendon Healing and Regeneration.Frontiers in cell and developmental biology · 2022Review
- Characterization of the structure, vascularity, and stem/progenitor cell populations in porcine Achilles tendon (PAT).Cell and tissue research · 2021Article
- Innovative Strategies in Tendon Tissue Engineering.Pharmaceutics · 2021Review
- Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology.Frontiers in cell and developmental biology · 2021Article
- The Role of Vascular Endothelial Growth Factor in Tendon Healing.Frontiers in physiology · 2021Review
- Mechanotransduction of stem cells for tendon repair.World journal of stem cells · 2020Review
- Review
- Transient Existence of Circulating Mesenchymal Stem Cells in the Deep Veins in Humans Following Long Bone Intramedullary Reaming.Journal of clinical medicine · 2020Article
- Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction.Nanoscale advances · 2020Review
- Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis.Cells · 2019Review
- The cellular basis of fibrotic tendon healing: challenges and opportunities.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendons and ligaments are often affected by mechanical injuries or chronic impairment but other than muscle or bone they possess a low healing capacity. So far, little is known about regeneration of tendons and the role of tendon precursor cells in that process. We hypothesize that perivascular cells of tendon capillaries are progenitors for functional tendon cells and are characterized by expression of marker genes and proteins typical for mesenchymal stem cells and functional tendon cells. Immunohistochemical characterization of biopsies derived from intact human supraspinatus tendons was performed. From these biopsies perivascular cells were isolated, cultured, and characterized using RT-PCR and Western blotting. We have shown for the first time that perivascular cells within tendon tissue express both tendon- and stem/precursor cell-like characteristics. These findings were confirmed by results from in vitro studies focusing on cultured perivascular cells isolated from human supraspinatus tendon biopsies. The results suggest that the perivascular niche may be considered a source for tendon precursor cells. This study provides further information about the molecular nature and localization of tendon precursor cells, which is the basis for developing novel strategies towards tendon healing and facilitated regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.