ArticleAnalytical and bioanalytical chemistry2009
Bioconjugation techniques for microfluidic biosensors.
Article in Analytical and bioanalytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 68 citations in OpenAlex.
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- Microfluidic Exponential Rolling Circle Amplification for Sensitive microRNA Detection Directly from Biological Samples.Sensors and actuators. B, Chemical · 2019Article
- Fast, Sensitive, and Quantitative Point-of-Care Platform for the Assessment of Drugs of Abuse in Urine, Serum, and Whole Blood.Analytical chemistry · 2017Article
- Versatile Bottom-Up Synthesis of Tethered Bilayer Lipid Membranes on Nanoelectronic Biosensor Devices.ACS applied materials & interfaces · 2017Article
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- Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation.Scientific reports · 2013Article
- Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.Nanophotonics (Berlin, Germany) · 2012Article
- Selective patterning of Si-based biosensor surfaces using isotropic silicon etchants.Journal of colloid and interface science · 2012Article
- Fiber surface modification technology for fiber-optic localized surface plasmon resonance biosensors.Sensors (Basel, Switzerland) · 2012Article
- Heterobifunctional modification of DNA for conjugation to solid surfaces.Analytical and bioanalytical chemistry · 2010Article
- Biopatterning for label-free detection.Colloids and surfaces. B, Biointerfaces · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have evaluated five bioconjugation chemistries for immobilizing DNA onto silicon substrates for microfluidic biosensing applications. Conjugation by organosilanes is compared with linkage by carbonyldiimidazole (CDI) activation of silanol groups and utilization of dendrimers. Chemistries were compared in terms of immobilization and hybridization density, stability under microfluidic flow-induced shear stress, and stability after extended storage in aqueous solutions. Conjugation by dendrimer tether provided the greatest hybridization efficiency; however, conjugation by aminosilane treated with glutaraldehyde yielded the greatest immobilization and hybridization densities, as well as enhanced stability to both shear stress and extended storage in an aqueous environment. Direct linkage by CDI activation provided sufficient immobilization and hybridization density and represents a novel DNA bioconjugation strategy. Although these chemistries were evaluated for use in microfluidic biosensors, the results provide meaningful insight to a number of nanobiotechnology applications for which microfluidic devices require surface biofunctionalization, for example vascular prostheses and implanted devices.
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