ArticleKidney international2009
Circulating transforming growth factor-beta1 levels and the risk for kidney disease in African Americans.
Article in Kidney international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Cardiometabolic comorbidities and complications of obesity and chronic kidney disease (CKD).Journal of clinical & translational endocrinology · 2024Review
- Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.Nature communications · 2023Article
- Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes.Science translational medicine · 2022Article
- The Serum from Patients with Secondary Frozen Shoulder Following Rotator Cuff Repair Induces Shoulder Capsule Fibrosis and Promotes Macrophage Polarization and Fibroblast Activation.Journal of inflammation research · 2021Article
- Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension.International journal of molecular sciences · 2019Review
- TGF-Beta Signaling in Bone with Chronic Kidney Disease.International journal of molecular sciences · 2018Review
- Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease.Oncotarget · 2016Article
- Hemocyanins Stimulate Innate Immunity by Inducing Different Temporal Patterns of Proinflammatory Cytokine Expression in Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy.The American journal of pathology · 2016Article
- Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria.PloS one · 2016Article
- A Randomized Controlled Trial of the Effects of Febuxostat Therapy on Adipokines and Markers of Kidney Fibrosis in Asymptomatic Hyperuricemic Patients With Diabetic Nephropathy.Canadian journal of kidney health and disease · 2016Article
- Clinical Relevance of Transforming Growth Factor-β1, Interleukin-6 and Haptoglobin for Prediction of Obesity Complications in Prepubertal Egyptian Children.Open access Macedonian journal of medical sciences · 2015Article
- Biomarkers in kidney fibrosis: are they useful?Kidney international supplements · 2014Review
- Immunosuppression preserves renal autoregulatory function and microvascular P2X(1) receptor reactivity in ANG II-hypertensive rats.American journal of physiology. Renal physiology · 2013Article
- Racial differences between blacks and whites with systemic sclerosis.Current opinion in rheumatology · 2012Review
- Urinary transforming growth factor beta-1 as a marker of renal dysfunction in sickle cell disease.Pediatric nephrology (Berlin, Germany) · 2011Article
- TGF-β1 serum concentration as a complementary diagnostic biomarker of lung cancer: establishment of a cut-point value.Journal of clinical laboratory analysis · 2011Article
- Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome.Cardiology research and practice · 2010Article
- Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population.Kidney international · 2009Article
- Transforming Growth Factor-Beta 1 and Endoglin Levels in Congenital Solitary Functioning Kidney.Indian journal of nephrologyArticle
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8 authors at 5 institutions in 1 country.
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Abstract
Transforming growth factor-beta1 (TGF-beta1) is known to induce progression of experimental renal disease. Here we determined whether there is an association between serum levels of TGF-beta1 and the risk factors for progression of clinically relevant renal disorders in 186 black and 147 white adults, none of whom had kidney disease or diabetes. Serum TGF-beta1 protein levels were positively and significantly associated with plasma renin activity along with the systolic and diastolic blood pressure in blacks but not whites after controlling for age, gender, and body mass index. These TGF-beta1 protein levels were also significantly associated with body mass index and metabolic syndrome and more predictive of microalbuminuria in blacks than in whites. The differential association between TGF-beta1 and renal disease risk factors in blacks and whites suggests an explanation for the excess burden of end-stage renal disease in the black population, but this requires validation in an independent cohort. Whether these findings show that it is the circulating levels of TGF-beta1 that contribute to renal disease progression or the findings reflect other unmeasured factors, further longitudinal studies are needed.
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