ArticleEpidemiology (Cambridge, Mass.)2009
Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility.
Article in Epidemiology (Cambridge, Mass.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Female alcohol consumption and fecundability: a systematic review and dose-response meta-analysis.Scientific reports · 2017Pooled it
- Nutritional modifications in male infertility: a systematic review covering 2 decades.Nutrition reviews · 2016Pooled it
- Preconception caffeine metabolites, caffeinated beverage intake, and fecundability.The American journal of clinical nutrition · 2022Trial
- Causal Relationship Between 38 Dietary Factors, Including Sugar and Alcohol Intakes, and Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Study.International journal of women's health · 2026Article
- Association between healthy beverage index and odds of diminished ovarian reserve in a case-control study.Scientific reports · 2025Article
- The Role of Diet in Women of Childbearing Age: Current Evidence Supporting Nutritional Recommendations.Nutrients · 2025Review
- Associations of dietary inflammatory indices (DII and E-DII) with sperm parameters.Clinical and experimental reproductive medicine · 2025Article
- Chronic Caffeine Consumption, Alone or Combined with Agomelatine or Quetiapine, Reduces the Maximum EEG Peak, As Linked to Cortical Neurodegeneration, Ovarian Estrogen Receptor Alpha, and Melatonin Receptor 2.Psychopharmacology · 2024Article
- Negative effects of ethanol on ovarian reserve and endometrium thickness: An animal study.Turkish journal of obstetrics and gynecology · 2024Article
- Common Beverage Consumption and Benign Gynecological Conditions.Beverages (Basel, Switzerland) · 2024Article
- Risk Factors for Infertility in Korean Women.Journal of Korean medical science · 2024Article
- Association between dietary inflammatory index and infertility of women; Results from RaNCD Cohort Study.Nutrition journal · 2023Article
- Perceived stress and markers of ovarian reserve among subfertile women.Reproductive biomedicine online · 2023Observational
- Lifestyle management in polycystic ovary syndrome - beyond diet and physical activity.BMC endocrine disorders · 2023Review
- Review
- The association between alcohol intake and fecundability during menstrual cycle phases.Human reproduction (Oxford, England) · 2021Article
- Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances.International journal of molecular sciences · 2021Review
- Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts.The American journal of clinical nutrition · 2020Article
- Smoke, alcohol and drug addiction and female fertility.Reproductive biology and endocrinology : RB&E · 2020Review
- Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations - FEBRASGO - Committee of Gynecological Endocrinology.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMany studies have examined whether caffeine, alcohol, or specific beverages containing these substances affect fertility in women. However, most of these studies have retrospectively collected information on alcohol and caffeine intake, making the results susceptible to biases.
methodsWe followed 18,555 married women without a history of infertility for 8 years as they attempted to become (or became) pregnant. Diet was measured twice during this period and prospectively related to the incidence of ovulatory disorder infertility.
resultsThere were 438 incident report of ovulatory disorder infertility during follow-up. Intakes of alcohol and caffeine were unrelated to the risk of ovulatory disorder infertility. Comparing the highest to lowest categories of intake, the multivariate-adjusted relative risk, was 1.11 (95% confidence interval = 0.76-1.64; P for trend 0.78) for alcohol and 0.86 (0.61-1.20; 0.44) for total caffeine. However, intake of caffeinated soft drinks was positively related to ovulatory disorder infertility. Comparing the highest to lowest categories of caffeinated soft drink consumption, the RR was 1.47 (1.09-1.98; 0.01). Similar associations were observed for noncaffeinated, sugared, diet, and total soft drinks.
conclusionsOur findings do not support the hypothesis that alcohol and caffeine impair ovulation to the point of decreasing fertility. The association between soft drinks and ovulatory disorder infertility seems not to be attributable to their caffeine or sugar content, and deserves further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.