ArticleInvestigative ophthalmology & visual science2009
Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- VEP estimation of visual acuity: a systematic review.Documenta ophthalmologica. Advances in ophthalmology · 2021Pooled it
- Therapeutic effect of the mesenchymal stem cells on vigabatrin-induced retinopathy in adult male albino rat.Anatomy & cell biology · 2022Article
- Trends and Costs Associated With the Diagnosis and Treatment of Infantile Spasms: A 10-Year Multicenter Retrospective Review.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- A New Contrast Sensitivity Test for Pediatric Patients: Feasibility and Inter-Examiner Reliability in Ocular Disorders and Cerebral Visual Impairment.Translational vision science & technology · 2020Article
- West Syndrome: A Review and Guide for Paediatricians.Clinical drug investigation · 2018Review
- Visuocortical function in infants with a history of neonatal jaundice.Investigative ophthalmology & visual science · 2014Article
- Contributing factors to VEP grating acuity deficit and inter-ocular acuity difference in children with cerebral visual impairment.Documenta ophthalmologica. Advances in ophthalmology · 2014Article
- Electroretinographic (ERG) responses in pediatric patients using vigabatrin.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.PloS one · 2012Article
- Evaluating risks for vigabatrin treatment.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo determine whether visual functions are decreased in children with infantile spasms and vigabatrin-attributed retinal toxicity.
methodsContrast sensitivity and grating acuity were measured by using sweep visual evoked potential (VEP) testing in 42 children with infantile spasms (mean age, 29.23 +/- 18.31 months). All children had been exposed to vigabatrin (VGB) for a minimum of 1 month. These children were divided into retinal toxicity and no toxicity groupings based on 30-Hz flicker amplitude reductions on the full-field electroretinogram. A multivariate analysis of variance (MANOVA) compared visual functions between children with and without retinal toxicity.
resultsThe MANOVA showed that visual function was significantly affected by VGB retinal toxicity. Further univariate analysis revealed that grating acuity was significantly reduced in children with toxicity. No differences in contrast sensitivity were found between children with toxicity and those without.
conclusionsReduced visual functions from VGB-attributed retinal toxicity can be detected in children with infantile spasms with the sweep VEP.
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Registered trials
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