ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The septate junction protein caspr is required for structural support and retention of KCNQ4 at calyceal synapses of vestibular hair cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- A Novel Striated Membrane Contact Site in Vestibular Hair Cells.Biology of the cell · 2026Article
- Autism associatedbioRxiv : the preprint server for biology · 2026Article
- Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment.The Journal of comparative neurology · 2026Article
- Transient capacitance changes recorded from vestibular type I hair cells are produced by GThe Journal of physiology · 2025Article
- Close Packing of Cells in Vestibular Epithelia Supports Local Electrical Potentials that Reduce Latency of Action Potential Generation.bioRxiv : the preprint server for biology · 2025Article
- Pimozide Inhibits Type II but Not Type I Hair Cells in Chicken Embryo and Adult Mouse Vestibular Organs.Biomedicines · 2024Article
- The potassium channel subunit KeLife · 2024Article
- The potassium channel subunit KbioRxiv : the preprint server for biology · 2024Article
- Vestibular hair cells are more prone to damage by excessive acceleration insult in the mouse with KCNQ4 dysfunction.Scientific reports · 2024Article
- Maturation of type I and type II rat vestibular hair cellsFrontiers in cell and developmental biology · 2024Article
- Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells.eLife · 2023Article
- The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans.Archives of toxicology · 2023Article
- Assessment of cochlear toxicity in response to chronic 3,3'-iminodipropionitrile in mice reveals early and reversible functional loss that precedes overt histopathology.Archives of toxicology · 2021Article
- Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021Article
- KNeuroscience · 2020Article
- Early auto-immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis.EMBO molecular medicine · 2018Article
- Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.Scientific reports · 2018Article
- An allosteric gating model recapitulates the biophysical properties of IThe Journal of physiology · 2017Article
- AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents.Journal of neurophysiology · 2017Article
- Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The afferent innervation contacting the type I hair cells of the vestibular sensory epithelia form distinct calyceal synapses. The apposed presynaptic and postsynaptic membranes at this large area of synaptic contact are kept at a remarkably regular distance. Here, we show by freeze-fracture electron microscopy that a patterned alignment of proteins at the calyceal membrane resembles a type of intercellular junction that is rare in vertebrates, the septate junction (SJ). We found that a core molecular component of SJs, Caspr, colocalizes with the K(+) channel KCNQ4 at the postsynaptic membranes of these calyceal synapses. Immunolabeling and ultrastructural analyses of Caspr knock-out mice reveal that, in the absence of Caspr, the separation between the membranes of the hair cells and the afferent neurons is conspicuously irregular and often increased by an order of magnitude. In these mutants, KCNQ4 fails to cluster at the postsynaptic membrane and appears diffused along the entire calyceal membrane. Our results indicate that a septate-like junction provides structural support to calyceal synaptic contact with the vestibular hair cell and that Caspr is required for the recruitment or retention of KCNQ4 at these synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.