ArticlePlant physiology2009
Cellular response of pea plants to cadmium toxicity: cross talk between reactive oxygen species, nitric oxide, and calcium.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
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Who cites it
155 citing papers in PubMed, 620 citations in OpenAlex.
- Foliar GR24 and γ-aminobutyric acid modulate redox signaling, root-system architecture, and mineral homeostasis in tellurite-stressed wheat (Plant signaling & behavior · 2026Article
- γ-aminobutyric acid is associated with calcium, reactive oxygen species, and nitric oxide responses and enhanced cadmium tolerance inPlant signaling & behavior · 2026Article
- Exogenous sorbitol-chelated calcium mitigates toxicity of cadmium in peanut seedlings through physiological, biochemical, and transcriptomic regulation.Frontiers in plant science · 2026Article
- Review
- Exploring the potential of signalling molecules hydrogen sulfide and nitric oxide in augmenting salt stress resilience in bitter gourd.BMC plant biology · 2025Article
- Review
- Jasmonic Acid Enhances Rice Cadmium Tolerance by Suppressing Cadmium Uptake and Translocation.Plants (Basel, Switzerland) · 2025Article
- Ameliorative effect of rhizobacteria Bradyrhizobium japonicum on antioxidant enzymes, cell viability and biochemistry in tomato plant under nematode stress.Scientific reports · 2025Article
- Melatonin improves the lead tolerance in Plantago ovata by modulating ROS homeostasis, phytohormone status and expression of stress-responsive genes.Plant cell reports · 2025Article
- Growth, physiological and molecular response of calcium and salicylic acid primed wheat under lead stress.Molecular biology reports · 2025Article
- Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species.BMC plant biology · 2025Article
- Integrative application of licorice root extract and melatonin improves faba bean growth and production in Cd-contaminated saline soil.BMC plant biology · 2025Article
- An Overview of the Mechanisms through Which Plants Regulate ROS Homeostasis under Cadmium Stress.Antioxidants (Basel, Switzerland) · 2024Review
- Silicon regulates phosphate deficiency through involvement of auxin and nitric oxide in barley roots.Planta · 2024Article
- Silicon nanoparticlesFrontiers in plant science · 2024Review
- Article
- Inhibition Roles of Calcium in Cadmium Uptake and Translocation in Rice: A Review.International journal of molecular sciences · 2023Review
- Effect of Thallium(I) on Growth, Nutrient Absorption, Photosynthetic Pigments, and Antioxidant Response ofAntioxidants (Basel, Switzerland) · 2023Article
- The Early Oxidative Stress Induced by Mercury and Cadmium Is Modulated by Ethylene inAntioxidants (Basel, Switzerland) · 2023Article
- Regulation of Reactive Oxygen Species during Salt Stress in Plants and Their Crosstalk with Other Signaling Molecules-Current Perspectives and Future Directions.Plants (Basel, Switzerland) · 2023Review
95 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) toxicity has been widely studied in different plant species; however, the mechanism involved in its toxicity as well as the cell response against the metal have not been well established. In this work, using pea (Pisum sativum) plants, we studied the effect of Cd on antioxidants, reactive oxygen species (ROS), and nitric oxide (NO) metabolism of leaves using different cellular, molecular, and biochemical approaches. The growth of pea plants with 50 mum CdCl(2) affected differentially the expression of superoxide dismutase (SOD) isozymes at both transcriptional and posttranscriptional levels, giving rise to a SOD activity reduction. The copper/zinc-SOD down-regulation was apparently due to the calcium (Ca) deficiency induced by the heavy metal. In these circumstances, the overproduction of the ROS hydrogen peroxide and superoxide could be observed in vivo by confocal laser microscopy, mainly associated with vascular tissue, epidermis, and mesophyll cells, and the production of superoxide radicals was prevented by exogenous Ca. On the other hand, the NO synthase-dependent NO production was strongly depressed by Cd, and treatment with Ca prevented this effect. Under these conditions, the pathogen-related proteins PrP4A and chitinase and the heat shock protein 71.2, were up-regulated, probably to protect cells against damages induced by Cd. The regulation of these proteins could be mediated by jasmonic acid and ethylene, whose contents increased by Cd treatment. A model is proposed for the cellular response to long-term Cd exposure consisting of cross talk between Ca, ROS, and NO.
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