ArticleNucleic acids research2009
The poly dA helix: a new structural motif for high performance DNA-based molecular switches.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Augmenting in vitro cancer cell toxicity via reactive oxygen species burst and glucose depletion induced by C14-Cu/Pt bimetallic nanozyme cascade reaction.Mikrochimica acta · 2026Article
- smDeepFLUOR: single-molecule deep learning fluorescence classification.Nature communications · 2026Article
- Uracil-Peptide-Pyrene Conjugates as CuChembiochem : a European journal of chemical biology · 2026Article
- Single-molecule fluorescence reveals the DNA unwinding mechanism of mitochondrial helicase TWINKLE and its interplay with single-stranded DNA-binding proteins.Nucleic acids research · 2025Article
- Structural basis for cooperative ssDNA binding by bacteriophage protein filament P12.Nucleic acids research · 2025Article
- Development of a Novel Colorimetric pH Biosensor Based on A-Motif Structures for Rapid Food Freshness Monitoring and Spoilage Detection.Biosensors · 2024Article
- Stacking correlation length in single-stranded DNA.Nucleic acids research · 2024Article
- A folding motif formed with an expanded genetic alphabet.Nature chemistry · 2024Article
- Template-based copying in chemically fuelled dynamic combinatorial libraries.Nature chemistry · 2024Article
- The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands.Acta crystallographica. Section D, Structural biology · 2022Article
- AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.Nucleic acids research · 2021Article
- A dissipative pathway for the structural evolution of DNA fibres.Nature chemistry · 2021Article
- Parallel poly(A) homo- and hetero-duplex formation detection with an adapted DNA nanoswitch technique.RNA (New York, N.Y.) · 2020Article
- Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition.Molecular cell · 2019Article
- A novel form of RNA double helix based on G·U and C·ARNA (New York, N.Y.) · 2018Article
- Influence of nucleotide modifications at the C2' position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA.Nucleic acids research · 2017Article
- In Vitro Selection of pH-Activated DNA Nanostructures.Angewandte Chemie (International ed. in English) · 2016Article
- Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation.Nucleic acids research · 2016Article
- Reprogramming the assembly of unmodified DNA with a small molecule.Nature chemistry · 2016Article
- A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.Journal of molecular biology · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a pH-dependent conformational transition in short, defined homopolymeric deoxyadenosines (dA(15)) from a single helical structure with stacked nucleobases at neutral pH to a double-helical, parallel-stranded duplex held together by AH(+)-H(+)A base pairs at acidic pH. Using native PAGE, 2D NMR, circular dichroism (CD) and fluorescence spectroscopy, we have characterized the two different pH dependent forms of dA(15). The pH-triggered transition between the two defined helical forms of dA(15) is characterized by CD and fluorescence. The kinetics of this conformational switch is found to occur on a millisecond time scale. This robust, highly reversible, pH-induced transition between the two well-defined structured states of dA(15) represents a new molecular building block for the construction of quick-response, pH-switchable architectures in structural DNA nanotechnology.
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