ArticleMolecular & cellular proteomics : MCP2009
The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina.
Article in Molecular & cellular proteomics : MCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Retinal proteomics in neurodegeneration: Insights into ocular and brain disorders.Neural regeneration research · 2026Article
- Outer nuclear layer thinning as an in vivo biomarker for discriminating probable FTLD-tau from probable FTLD-TDP with PET-supported subtyping.Alzheimer's research & therapy · 2026Article
- Retinal Impairments in Mice Lacking Both Nxnl1 and Nxnl2 Genes.Investigative ophthalmology & visual science · 2025Article
- Retinal imaging and tissue analysis for frontotemporal degeneration: recent advances and challenges for biomarker development.Journal of neurology, neurosurgery, and psychiatry · 2025Review
- An overview of the two-component system GarR/GarS role on antibiotic production in Streptomyces coelicolor.Applied microbiology and biotechnology · 2024Article
- Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease.Neurobiology of aging · 2023Article
- Nucleoredoxin-like 2 metabolic signaling impairs its potential contribution to neurodegenerative diseases.Neural regeneration research · 2023Article
- Article
- The Emergence of Rod-Cone Cellular Interaction.Frontiers in genetics · 2022Article
- Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau.Acta neuropathologica communications · 2021Article
- The plasma peptides of Alzheimer's disease.Clinical proteomics · 2021Article
- Insulin inhibits inflammation-induced cone death in retinal detachment.Journal of neuroinflammation · 2020Article
- Functional Genomics of the Retina to Elucidate its Construction and Deconstruction.International journal of molecular sciences · 2019Review
- A Mathematical Analysis of Aerobic Glycolysis Triggered by Glucose Uptake in Cones.Scientific reports · 2019Article
- Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?International journal of molecular sciences · 2019Review
- Metabolic and redox signaling in the retina.Cellular and molecular life sciences : CMLS · 2017Review
- Gene therapy approaches for the treatment of retinal disorders.Discovery medicine · 2016Review
- Advances in Gene Therapy for Diseases of the Eye.Human gene therapy · 2016Review
- Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration.The Journal of clinical investigation · 2015Article
- Vibratome sectioning mouse retina to prepare photoreceptor cultures.Journal of visualized experiments : JoVE · 2014Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rod-derived cone viability factor (RdCVF) is produced by the Nxnl1 gene that codes for a second polypeptide, RdCVFL, by alternative splicing. Although the role of RdCVF in promoting cone survival has been described, the implication of RdCVFL, a putative thioredoxin enzyme, in the protection of photoreceptors is presently unknown. Using a proteomics approach we identified 90 proteins interacting with RdCVFL including the microtubule-binding protein TAU. We demonstrate that the level of phosphorylation of TAU is increased in the retina of the Nxnl1(-/-) mice as it is hyperphosphorylated in the brain of patients suffering from Alzheimer disease, presumably in some cases through oxidative stress. Using a cell-based assay, we show that RdCVFL inhibits TAU phosphorylation. In vitro, RdCVFL protects TAU from oxidative damage. Photooxidative stress is implicated in retinal degeneration, particularly in retinitis pigmentosa, where it is considered to be a contributor to secondary cone death. The functional interaction between RdCVFL and TAU described here is the first characterization of the RdCVFL signaling pathway involved in neuronal cell death mediated by oxidative stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.