ArticleThe Journal of biological chemistry2009
Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cytoprotective role of octacosanol in lipopolysaccharide-induced inflammation.Frontiers in immunology · 2026Article
- Adhesion strength and contractility enable metastatic cells to become adurotactic.Cell reports · 2021Article
- Hemidesmosome-Related Keratin Filament Bundling and Nucleation.International journal of molecular sciences · 2021Article
- Filamin A mediates isotropic distribution of applied force across the actin network.The Journal of cell biology · 2019Article
- The tale of two talins - two isoforms to fine-tune integrin signalling.FEBS letters · 2018Review
- Single and collective cell migration: the mechanics of adhesions.Molecular biology of the cell · 2017Article
- The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.Frontiers in molecular neuroscience · 2017Article
- Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.Experimental cell research · 2016Review
- Selective Role of Vinculin in Contractile Mechanisms of Endothelial Permeability.American journal of respiratory cell and molecular biology · 2016Article
- Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.Nature cell biology · 2016Article
- Vinculin controls talin engagement with the actomyosin machinery.Nature communications · 2015Article
- In vivo quantitative analysis of Talin turnover in response to force.Molecular biology of the cell · 2015Article
- Mechanisms of talin-dependent integrin signaling and crosstalk.Biochimica et biophysica acta · 2014Review
- Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions.Nature cell biology · 2012Article
- Unanchoring integrins in focal adhesions.Nature cell biology · 2012Article
- Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration.Scientific reports · 2012Article
- The C terminus of talin links integrins to cell cycle progression.The Journal of cell biology · 2011Article
- Cooperativity between integrin activation and mechanical stress leads to integrin clustering.Biophysical journal · 2011Article
- Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression.Cold Spring Harbor perspectives in biology · 2011Review
- Central region of talin has a unique fold that binds vinculin and actin.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cell-extracellular matrix junctions (focal adhesions), the cytoskeletal protein talin is central to the connection of integrins to the actin cytoskeleton. Talin is thought to mediate this connection via its two integrin, (at least) three actin, and several vinculin binding sites. The binding sites are cryptic in the head-to-rod autoinhibited cytoplasmic form of the protein and require (stepwise) conformational activation. This activation process, however, remains poorly understood, and there are contradictory models with respect to the determinants of adhesion site localization. Here, we report turnover rates and protein-protein interactions in a range of talin rod domain constructs varying in helix bundle structure. We conclude that several bundles of the C terminus cooperate to regulate targeting and concomitantly tailor high affinity interactions of the talin rod in cell adhesions. Intrinsic control of ligand binding activities is essential for the coordination of adhesion site function of talin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.